Insomnia in Cornelia de Lange Syndrome

Roy Rajan, James R. Benke, Antonie D. Kline, Howard P. Levy, Amy Kimball, Tiffany L. Mettel, Emily F. Boss, Stacey L. Ishman

Research output: Contribution to journalArticle

Abstract

Objective: Up to 55% of patients with Cornelia de Lange Syndrome (CdLS) experience sleep disturbance. Prior evaluation of children without CdLS with similar intellectual disability and self-injurious behavior suggests that sleep disturbances may be related to insomnia or circadian issues. Methods: Caregivers of 31 patients (19 children) with CdLS completed a sleep history questionnaire focused on sleep patterns and evening sleep behavior to screen for signs and symptoms of insomnia and circadian rhythm disorders. Results: The mean age of participants was 14.5 years (range 0.6-37). Major difficulty in falling asleep (75% pediatric, 33% adult) and staying asleep (52% pediatric, 33% adult) was noted. Overall, time to sleep onset was 27.0 ± 17.6. min, however in those with stated sleep onset difficulty, average time to sleep was 37.8 ± 16.4. min (p=0.002). The mean number of pediatric nighttime awakenings was 1.5 overall and 2.1 in those with stated sleep maintenance difficulties versus 0.7 and 1.5 respectively in adults. Children with CdLS tended to fall back asleep slower (61.8. min) than adults (14.9. min), but none of the comparisons between adult and pediatric sleep measures were significant. Greater than half of participants reported a family member with a possible circadian rhythm disorder. Conclusions: Symptoms suggestive of insomnia or circadian rhythm disorder are prevalent in this cohort of children and adults with CdLS. Adults may have less severe symptoms than children, suggesting some improvement over time although this study is underpowered for this analysis. Further studies are necessary to better characterize sleep disturbance in the CdLS population.

Original languageEnglish (US)
Pages (from-to)972-975
Number of pages4
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume76
Issue number7
DOIs
StatePublished - Jul 1 2012

Keywords

  • Cornelia de Lange Syndrome
  • Insomnia
  • Sleep
  • Sleepiness

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Insomnia in Cornelia de Lange Syndrome'. Together they form a unique fingerprint.

  • Cite this