TY - JOUR
T1 - Insights into the Structure, Function, and Dynamics of the Bacterial Cytokinetic FtsZ-Ring
AU - McQuillen, Ryan
AU - Xiao, Jie
N1 - Publisher Copyright:
© 2020 by Annual Reviews. All rights reserved.
PY - 2020/5/6
Y1 - 2020/5/6
N2 - The FtsZ protein is a highly conserved bacterial tubulin homolog. In vivo, the functional form of FtsZ is the polymeric, ring-like structure (Z-ring) assembled at the future division site during cell division. While it is clear that the Z-ring plays an essential role in orchestrating cytokinesis, precisely what its functions are and how these functions are achieved remain elusive. In this article, we review what we have learned during the past decade about the Z-ring's structure, function, and dynamics, with a particular focus on insights generated by recent high-resolution imaging and single-molecule analyses. We suggest that the major function of the Z-ring is to govern nascent cell pole morphogenesis by directing the spatiotemporal distribution of septal cell wall remodeling enzymes through the Z-ring's GTP hydrolysis-dependent treadmilling dynamics. In this role, FtsZ functions in cell division as the counterpart of the cell shape-determining actin homolog MreB in cell elongation.
AB - The FtsZ protein is a highly conserved bacterial tubulin homolog. In vivo, the functional form of FtsZ is the polymeric, ring-like structure (Z-ring) assembled at the future division site during cell division. While it is clear that the Z-ring plays an essential role in orchestrating cytokinesis, precisely what its functions are and how these functions are achieved remain elusive. In this article, we review what we have learned during the past decade about the Z-ring's structure, function, and dynamics, with a particular focus on insights generated by recent high-resolution imaging and single-molecule analyses. We suggest that the major function of the Z-ring is to govern nascent cell pole morphogenesis by directing the spatiotemporal distribution of septal cell wall remodeling enzymes through the Z-ring's GTP hydrolysis-dependent treadmilling dynamics. In this role, FtsZ functions in cell division as the counterpart of the cell shape-determining actin homolog MreB in cell elongation.
KW - FtsZ
KW - bacterial cell division
KW - cell wall constriction
KW - cytoskeleton dynamics
KW - septum synthesis
KW - single-molecule imaging
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U2 - 10.1146/annurev-biophys-121219-081703
DO - 10.1146/annurev-biophys-121219-081703
M3 - Review article
C2 - 32092282
AN - SCOPUS:85084326818
SN - 1936-122X
VL - 49
SP - 309
EP - 341
JO - Annual Review of Biophysics
JF - Annual Review of Biophysics
ER -