Abstract
Somatic mosaicism refers to the fact that cells within an organism have different genomes. It is now clear that somatic mosaicism occurs in all brains and that somatic mutations in a subset of cells can cause various rare neurodevelopmental disorders. However, for most individuals, the extent and consequences of somatic mosaicism are largely unknown. The complexity and unique features of the brain suggest that somatic mosaicism can play an important role in behavior and cognition. Here we review recent manuscripts showing instances of somatic mosaicism in the brain and estimating its extent and possible biological consequences. The consequences of somatic mosaicism span vast dimensions -from a single-locus variant, to genes and gene networks, to cells, to the interactions of the mosaic cells via neural networks affecting behavior and cognition. We highlight how systems biology approaches are particularly well suited for the complex emerging field of brain somatic mosaicism.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 90-94 |
| Number of pages | 5 |
| Journal | Current Opinion in Systems Biology |
| Volume | 1 |
| DOIs | |
| State | Published - Feb 1 2017 |
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Keywords
- Brain development
- Mutation
- Retrotransposition
- Somatic mosaicism
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Computer Science Applications
- Drug Discovery
- Applied Mathematics
- Modeling and Simulation
Cite this
Insights into the role of somatic mosaicism in the brain. / Paquola, Apua; Erwin, Jennifer; Gage, Fred H.
In: Current Opinion in Systems Biology, Vol. 1, 01.02.2017, p. 90-94.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Insights into the role of somatic mosaicism in the brain
AU - Paquola, Apua
AU - Erwin, Jennifer
AU - Gage, Fred H.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Somatic mosaicism refers to the fact that cells within an organism have different genomes. It is now clear that somatic mosaicism occurs in all brains and that somatic mutations in a subset of cells can cause various rare neurodevelopmental disorders. However, for most individuals, the extent and consequences of somatic mosaicism are largely unknown. The complexity and unique features of the brain suggest that somatic mosaicism can play an important role in behavior and cognition. Here we review recent manuscripts showing instances of somatic mosaicism in the brain and estimating its extent and possible biological consequences. The consequences of somatic mosaicism span vast dimensions -from a single-locus variant, to genes and gene networks, to cells, to the interactions of the mosaic cells via neural networks affecting behavior and cognition. We highlight how systems biology approaches are particularly well suited for the complex emerging field of brain somatic mosaicism.
AB - Somatic mosaicism refers to the fact that cells within an organism have different genomes. It is now clear that somatic mosaicism occurs in all brains and that somatic mutations in a subset of cells can cause various rare neurodevelopmental disorders. However, for most individuals, the extent and consequences of somatic mosaicism are largely unknown. The complexity and unique features of the brain suggest that somatic mosaicism can play an important role in behavior and cognition. Here we review recent manuscripts showing instances of somatic mosaicism in the brain and estimating its extent and possible biological consequences. The consequences of somatic mosaicism span vast dimensions -from a single-locus variant, to genes and gene networks, to cells, to the interactions of the mosaic cells via neural networks affecting behavior and cognition. We highlight how systems biology approaches are particularly well suited for the complex emerging field of brain somatic mosaicism.
KW - Brain development
KW - Mutation
KW - Retrotransposition
KW - Somatic mosaicism
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UR - http://www.scopus.com/inward/citedby.url?scp=85044052856&partnerID=8YFLogxK
U2 - 10.1016/j.coisb.2016.12.004
DO - 10.1016/j.coisb.2016.12.004
M3 - Review article
C2 - 29226270
AN - SCOPUS:85044052856
VL - 1
SP - 90
EP - 94
JO - Current Opinion in Systems Biology
JF - Current Opinion in Systems Biology
SN - 2452-3100
ER -