Insights into the role of somatic mosaicism in the brain

Research output: Contribution to journalReview article

Abstract

Somatic mosaicism refers to the fact that cells within an organism have different genomes. It is now clear that somatic mosaicism occurs in all brains and that somatic mutations in a subset of cells can cause various rare neurodevelopmental disorders. However, for most individuals, the extent and consequences of somatic mosaicism are largely unknown. The complexity and unique features of the brain suggest that somatic mosaicism can play an important role in behavior and cognition. Here we review recent manuscripts showing instances of somatic mosaicism in the brain and estimating its extent and possible biological consequences. The consequences of somatic mosaicism span vast dimensions -from a single-locus variant, to genes and gene networks, to cells, to the interactions of the mosaic cells via neural networks affecting behavior and cognition. We highlight how systems biology approaches are particularly well suited for the complex emerging field of brain somatic mosaicism.

Original languageEnglish (US)
Pages (from-to)90-94
Number of pages5
JournalCurrent Opinion in Systems Biology
Volume1
DOIs
StatePublished - Feb 1 2017

Fingerprint

Mosaicism
Brain
Genes
Cell
Cognition
Gene Networks
Systems Biology
Locus
Disorder
Mutation
Genome
Neural Networks
Gene
Neural networks
Manuscripts
Gene Regulatory Networks
Unknown
Subset
Cell Communication
Interaction

Keywords

  • Brain development
  • Mutation
  • Retrotransposition
  • Somatic mosaicism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Computer Science Applications
  • Drug Discovery
  • Applied Mathematics
  • Modeling and Simulation

Cite this

Insights into the role of somatic mosaicism in the brain. / Paquola, Apua; Erwin, Jennifer; Gage, Fred H.

In: Current Opinion in Systems Biology, Vol. 1, 01.02.2017, p. 90-94.

Research output: Contribution to journalReview article

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