Insights into the Molecular Mechanism of Membrane Fusion from Simulation

Evidence for the Association of Splayed Tails

Mark J. Stevens, Jan H. Hoh, Thomas B Woolf

Research output: Contribution to journalArticle

Abstract

The coarse-grained simulations of fusion between two liposomes, from which a detailed picture of lipid movement emerges, were discussed. It is found that the bilayers dilate at the contact edge, and the resulting increase in the area per lipid produces a tilting of the individual molecules. In simulation, the splayed lipids tend to orient such that their aliphatic tails contact each other creating the beginnings of a hydrophobic core. Results suggest that conformation properties of lipids plays an important role in fusion.

Original languageEnglish (US)
Pages (from-to)1881021-1881024
Number of pages4
JournalPhysical Review Letters
Volume91
Issue number18
StatePublished - Oct 31 2003

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Membrane Fusion
lipids
fusion
membranes
Lipids
simulation
Liposomes
molecules

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Medicine(all)

Cite this

Insights into the Molecular Mechanism of Membrane Fusion from Simulation : Evidence for the Association of Splayed Tails. / Stevens, Mark J.; Hoh, Jan H.; Woolf, Thomas B.

In: Physical Review Letters, Vol. 91, No. 18, 31.10.2003, p. 1881021-1881024.

Research output: Contribution to journalArticle

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