Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis

David Andes, Arturo Casadevall

Research output: Contribution to journalArticle

Abstract

In 2012 the medical community in the United States faced an unprecedented outbreak of fungal meningitis caused by Exserohilum rostratum associated with injections of contaminated lots of methyprednilsone acetate. Rapid response by public health authorities led to the identification of the cause of the outbreak and the epidemic quickly abated, even though new cases were still being reported many months later. Although the cause of the outbreak is known there are many uncertainties regarding the management of infected individuals and the long term risk for those who were exposed to this organism. The epidemic of E. rostratum infections illustrates how an organism that normally has low pathogenic potential for humans can transform into a very dangerous pathogen when conditions are changed such that skin barriers are breached while it is simultaneously delivered with an immunosuppressive drug. Furthermore, this epidemic highlights the potential threats to human and animal health from the fungal kingdom.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalFungal Genetics and Biology
Volume61
DOIs
StatePublished - Dec 2013
Externally publishedYes

Fingerprint

Fungal Meningitis
Disease Outbreaks
Immunosuppressive Agents
Uncertainty
Acetates
Public Health
Skin
Injections
Health
Infection
Pharmaceutical Preparations

Keywords

  • Exserohilum rostratum
  • Fungal
  • Meningistis

ASJC Scopus subject areas

  • Genetics
  • Microbiology

Cite this

Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis. / Andes, David; Casadevall, Arturo.

In: Fungal Genetics and Biology, Vol. 61, 12.2013, p. 143-145.

Research output: Contribution to journalArticle

@article{3b435b15a9904f94a9b26864cb53e32d,
title = "Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis",
abstract = "In 2012 the medical community in the United States faced an unprecedented outbreak of fungal meningitis caused by Exserohilum rostratum associated with injections of contaminated lots of methyprednilsone acetate. Rapid response by public health authorities led to the identification of the cause of the outbreak and the epidemic quickly abated, even though new cases were still being reported many months later. Although the cause of the outbreak is known there are many uncertainties regarding the management of infected individuals and the long term risk for those who were exposed to this organism. The epidemic of E. rostratum infections illustrates how an organism that normally has low pathogenic potential for humans can transform into a very dangerous pathogen when conditions are changed such that skin barriers are breached while it is simultaneously delivered with an immunosuppressive drug. Furthermore, this epidemic highlights the potential threats to human and animal health from the fungal kingdom.",
keywords = "Exserohilum rostratum, Fungal, Meningistis",
author = "David Andes and Arturo Casadevall",
year = "2013",
month = "12",
doi = "10.1016/j.fgb.2013.08.014",
language = "English (US)",
volume = "61",
pages = "143--145",
journal = "Fungal Genetics and Biology",
issn = "1087-1845",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis

AU - Andes, David

AU - Casadevall, Arturo

PY - 2013/12

Y1 - 2013/12

N2 - In 2012 the medical community in the United States faced an unprecedented outbreak of fungal meningitis caused by Exserohilum rostratum associated with injections of contaminated lots of methyprednilsone acetate. Rapid response by public health authorities led to the identification of the cause of the outbreak and the epidemic quickly abated, even though new cases were still being reported many months later. Although the cause of the outbreak is known there are many uncertainties regarding the management of infected individuals and the long term risk for those who were exposed to this organism. The epidemic of E. rostratum infections illustrates how an organism that normally has low pathogenic potential for humans can transform into a very dangerous pathogen when conditions are changed such that skin barriers are breached while it is simultaneously delivered with an immunosuppressive drug. Furthermore, this epidemic highlights the potential threats to human and animal health from the fungal kingdom.

AB - In 2012 the medical community in the United States faced an unprecedented outbreak of fungal meningitis caused by Exserohilum rostratum associated with injections of contaminated lots of methyprednilsone acetate. Rapid response by public health authorities led to the identification of the cause of the outbreak and the epidemic quickly abated, even though new cases were still being reported many months later. Although the cause of the outbreak is known there are many uncertainties regarding the management of infected individuals and the long term risk for those who were exposed to this organism. The epidemic of E. rostratum infections illustrates how an organism that normally has low pathogenic potential for humans can transform into a very dangerous pathogen when conditions are changed such that skin barriers are breached while it is simultaneously delivered with an immunosuppressive drug. Furthermore, this epidemic highlights the potential threats to human and animal health from the fungal kingdom.

KW - Exserohilum rostratum

KW - Fungal

KW - Meningistis

UR - http://www.scopus.com/inward/record.url?scp=84887816380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887816380&partnerID=8YFLogxK

U2 - 10.1016/j.fgb.2013.08.014

DO - 10.1016/j.fgb.2013.08.014

M3 - Article

VL - 61

SP - 143

EP - 145

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

SN - 1087-1845

ER -