TY - CHAP
T1 - Insights from magnetic resonance imaging
AU - Filippi, Massimo
AU - Charil, Arnaud
AU - Rovaris, Marco
AU - Absinta, Martina
AU - Rocca, Maria Assunta
PY - 2014
Y1 - 2014
N2 - Recent years have witnessed impressive advancements in the use of magnetic resonance imaging (MRI) for the assessment of patients with multiple sclerosis (MS). Complementary to the clinical evaluation, conventional MRI (cMRI) provides crucial pieces of information for the diagnosis of MS, the understanding of its natural history, and monitoring the efficacy of experimental treatments. Measures derived from cMRI present clear advantages over the clinical assessment, including their more objective nature and an increased sensitivity to MS-related changes. However, the correlation between these measures and the clinical manifestations of the disease remains weak, and this can be explained, at least partially, by the limited ability of cMRI to characterize and quantify the heterogeneous features of MS pathology. Quantitative MR-based techniques have the potential to overcome the limitations of cMRI. Magnetization transfer MRI, diffusion-weighted and diffusion tensor MRI with fiber tractography, proton magnetic resonance spectroscopy, T1 and T2 relaxation time measurement, and functional MRI are contributing to elucidate the mechanisms that underlie injury, repair, and functional adaptation in patients with MS. All conventional and nonconventional MR techniques will benefit from the use of high-field MR systems (3.0. T or more).
AB - Recent years have witnessed impressive advancements in the use of magnetic resonance imaging (MRI) for the assessment of patients with multiple sclerosis (MS). Complementary to the clinical evaluation, conventional MRI (cMRI) provides crucial pieces of information for the diagnosis of MS, the understanding of its natural history, and monitoring the efficacy of experimental treatments. Measures derived from cMRI present clear advantages over the clinical assessment, including their more objective nature and an increased sensitivity to MS-related changes. However, the correlation between these measures and the clinical manifestations of the disease remains weak, and this can be explained, at least partially, by the limited ability of cMRI to characterize and quantify the heterogeneous features of MS pathology. Quantitative MR-based techniques have the potential to overcome the limitations of cMRI. Magnetization transfer MRI, diffusion-weighted and diffusion tensor MRI with fiber tractography, proton magnetic resonance spectroscopy, T1 and T2 relaxation time measurement, and functional MRI are contributing to elucidate the mechanisms that underlie injury, repair, and functional adaptation in patients with MS. All conventional and nonconventional MR techniques will benefit from the use of high-field MR systems (3.0. T or more).
KW - Diffusion tensor imaging
KW - Functional MRI
KW - High-field MRI
KW - MRI
KW - Magnetic resonance imaging
KW - Magnetic resonance spectroscopy
KW - Magnetization transfer imaging
UR - http://www.scopus.com/inward/record.url?scp=84893440328&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893440328&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-52001-2.00006-6
DO - 10.1016/B978-0-444-52001-2.00006-6
M3 - Chapter
C2 - 24507516
AN - SCOPUS:84893440328
T3 - Handbook of Clinical Neurology
SP - 115
EP - 149
BT - Handbook of Clinical Neurology
PB - Elsevier B.V.
ER -