Insights from clonal expansion and hiv persistence in perinatal infections

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The latent HIV reservoir forms early in the course of infection and is main-tained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of the reservoir through early ART. However, a greater understanding of the persistence of the integrated proviruses is needed for targeting the residual proviruses that form barriers to cure. A study was performed by Bale and Katusiime et al. (M. J. Bale, M. G. Katusiime, D. Wells, X. Wu, et al., mBio 12:e00568-21, 2021, using in-depth integration site analysis in 11 children before ART and after up to nine years of ART. They have identified early development of long-lived proviruses, although the replication competence is unknown. A small fraction of cells bearing integrated proviruses clonally expand early during infection and persist. Integration in the onco-genes STAT5B and BACH2 were also found; these findings confirm the early development of clonal proliferation in perinatal HIV infection despite early effective ART, with a propensity for oncogenes.

Original languageEnglish (US)
Article numbere00983-21
Issue number4
StatePublished - Aug 2021


  • Clonal expansion
  • Human immunodeficiency virus
  • Latent reservoir
  • Perinatal infections

ASJC Scopus subject areas

  • Microbiology
  • Virology


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