TY - JOUR
T1 - Insights from clonal expansion and hiv persistence in perinatal infections
AU - Dhummakupt, Adit
AU - Persaud, Deborah
N1 - Publisher Copyright:
© 2021, American Society for Microbiology. All rights reserved.
PY - 2021/8
Y1 - 2021/8
N2 - The latent HIV reservoir forms early in the course of infection and is main-tained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of the reservoir through early ART. However, a greater understanding of the persistence of the integrated proviruses is needed for targeting the residual proviruses that form barriers to cure. A study was performed by Bale and Katusiime et al. (M. J. Bale, M. G. Katusiime, D. Wells, X. Wu, et al., mBio 12:e00568-21, 2021, https://doi.org/10.1128/mBio.00568-21) using in-depth integration site analysis in 11 children before ART and after up to nine years of ART. They have identified early development of long-lived proviruses, although the replication competence is unknown. A small fraction of cells bearing integrated proviruses clonally expand early during infection and persist. Integration in the onco-genes STAT5B and BACH2 were also found; these findings confirm the early development of clonal proliferation in perinatal HIV infection despite early effective ART, with a propensity for oncogenes.
AB - The latent HIV reservoir forms early in the course of infection and is main-tained for life despite effective antiretroviral treatment (ART), including early treatment. Perinatal HIV infection presents a unique opportunity to limit seeding of the reservoir through early ART. However, a greater understanding of the persistence of the integrated proviruses is needed for targeting the residual proviruses that form barriers to cure. A study was performed by Bale and Katusiime et al. (M. J. Bale, M. G. Katusiime, D. Wells, X. Wu, et al., mBio 12:e00568-21, 2021, https://doi.org/10.1128/mBio.00568-21) using in-depth integration site analysis in 11 children before ART and after up to nine years of ART. They have identified early development of long-lived proviruses, although the replication competence is unknown. A small fraction of cells bearing integrated proviruses clonally expand early during infection and persist. Integration in the onco-genes STAT5B and BACH2 were also found; these findings confirm the early development of clonal proliferation in perinatal HIV infection despite early effective ART, with a propensity for oncogenes.
KW - Clonal expansion
KW - Human immunodeficiency virus
KW - Latent reservoir
KW - Perinatal infections
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U2 - 10.1128/mBio.00983-21
DO - 10.1128/mBio.00983-21
M3 - Article
C2 - 34425702
AN - SCOPUS:85114012586
SN - 2161-2129
VL - 12
JO - mBio
JF - mBio
IS - 4
M1 - e00983-21
ER -