Insight into treatment of HIV infection from viral dynamics models

Alison L. Hill, Daniel I.S. Rosenbloom, Martin A. Nowak, Robert F Siliciano

Research output: Contribution to journalArticle

Abstract

The odds of living a long and healthy life with HIV infection have dramatically improved with the advent of combination antiretroviral therapy. Along with the early development and clinical trials of these drugs, and new field of research emerged called viral dynamics, which uses mathematical models to interpret and predict the time-course of viral levels during infection and how they are altered by treatment. In this review, we summarize the contributions that virus dynamics models have made to understanding the pathophysiology of infection and to designing effective therapies. This includes studies of the multiphasic decay of viral load when antiretroviral therapy is given, the evolution of drug resistance, the long-term persistence latently infected cells, and the rebound of viremia when drugs are stopped. We additionally discuss new work applying viral dynamics models to new classes of investigational treatment for HIV, including latency-reversing agents and immunotherapy.

Original languageEnglish (US)
Pages (from-to)9-25
Number of pages17
JournalImmunological Reviews
Volume285
Issue number1
DOIs
StatePublished - Sep 1 2018

Fingerprint

HIV Infections
Investigational Therapies
Viremia
Therapeutics
Infection
Viral Load
Drug Resistance
Pharmaceutical Preparations
Immunotherapy
Theoretical Models
Clinical Trials
HIV
Viruses
Research

Keywords

  • antiretroviral therapy
  • cure
  • HIV
  • pharmacodynamics
  • viral dynamics model
  • viral rebound

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Insight into treatment of HIV infection from viral dynamics models. / Hill, Alison L.; Rosenbloom, Daniel I.S.; Nowak, Martin A.; Siliciano, Robert F.

In: Immunological Reviews, Vol. 285, No. 1, 01.09.2018, p. 9-25.

Research output: Contribution to journalArticle

Hill, Alison L. ; Rosenbloom, Daniel I.S. ; Nowak, Martin A. ; Siliciano, Robert F. / Insight into treatment of HIV infection from viral dynamics models. In: Immunological Reviews. 2018 ; Vol. 285, No. 1. pp. 9-25.
@article{76b08a9360364f66b21ac33f59ac7df1,
title = "Insight into treatment of HIV infection from viral dynamics models",
abstract = "The odds of living a long and healthy life with HIV infection have dramatically improved with the advent of combination antiretroviral therapy. Along with the early development and clinical trials of these drugs, and new field of research emerged called viral dynamics, which uses mathematical models to interpret and predict the time-course of viral levels during infection and how they are altered by treatment. In this review, we summarize the contributions that virus dynamics models have made to understanding the pathophysiology of infection and to designing effective therapies. This includes studies of the multiphasic decay of viral load when antiretroviral therapy is given, the evolution of drug resistance, the long-term persistence latently infected cells, and the rebound of viremia when drugs are stopped. We additionally discuss new work applying viral dynamics models to new classes of investigational treatment for HIV, including latency-reversing agents and immunotherapy.",
keywords = "antiretroviral therapy, cure, HIV, pharmacodynamics, viral dynamics model, viral rebound",
author = "Hill, {Alison L.} and Rosenbloom, {Daniel I.S.} and Nowak, {Martin A.} and Siliciano, {Robert F}",
year = "2018",
month = "9",
day = "1",
doi = "10.1111/imr.12698",
language = "English (US)",
volume = "285",
pages = "9--25",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Insight into treatment of HIV infection from viral dynamics models

AU - Hill, Alison L.

AU - Rosenbloom, Daniel I.S.

AU - Nowak, Martin A.

AU - Siliciano, Robert F

PY - 2018/9/1

Y1 - 2018/9/1

N2 - The odds of living a long and healthy life with HIV infection have dramatically improved with the advent of combination antiretroviral therapy. Along with the early development and clinical trials of these drugs, and new field of research emerged called viral dynamics, which uses mathematical models to interpret and predict the time-course of viral levels during infection and how they are altered by treatment. In this review, we summarize the contributions that virus dynamics models have made to understanding the pathophysiology of infection and to designing effective therapies. This includes studies of the multiphasic decay of viral load when antiretroviral therapy is given, the evolution of drug resistance, the long-term persistence latently infected cells, and the rebound of viremia when drugs are stopped. We additionally discuss new work applying viral dynamics models to new classes of investigational treatment for HIV, including latency-reversing agents and immunotherapy.

AB - The odds of living a long and healthy life with HIV infection have dramatically improved with the advent of combination antiretroviral therapy. Along with the early development and clinical trials of these drugs, and new field of research emerged called viral dynamics, which uses mathematical models to interpret and predict the time-course of viral levels during infection and how they are altered by treatment. In this review, we summarize the contributions that virus dynamics models have made to understanding the pathophysiology of infection and to designing effective therapies. This includes studies of the multiphasic decay of viral load when antiretroviral therapy is given, the evolution of drug resistance, the long-term persistence latently infected cells, and the rebound of viremia when drugs are stopped. We additionally discuss new work applying viral dynamics models to new classes of investigational treatment for HIV, including latency-reversing agents and immunotherapy.

KW - antiretroviral therapy

KW - cure

KW - HIV

KW - pharmacodynamics

KW - viral dynamics model

KW - viral rebound

UR - http://www.scopus.com/inward/record.url?scp=85051422635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051422635&partnerID=8YFLogxK

U2 - 10.1111/imr.12698

DO - 10.1111/imr.12698

M3 - Article

C2 - 30129208

AN - SCOPUS:85051422635

VL - 285

SP - 9

EP - 25

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -