TY - JOUR
T1 - Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes
AU - Feng, Yan
AU - Niu, Tianhua
AU - Xu, Xin
AU - Chen, Changzhong
AU - Li, Qiongfang
AU - Qian, Rongli
AU - Wang, Guoying
AU - Xu, Xiping
PY - 2002
Y1 - 2002
N2 - In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (X21 = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.
AB - In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (X21 = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.
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U2 - 10.2337/diabetes.51.6.1986
DO - 10.2337/diabetes.51.6.1986
M3 - Article
C2 - 12031990
AN - SCOPUS:0036263769
SN - 0012-1797
VL - 51
SP - 1986
EP - 1988
JO - Diabetes
JF - Diabetes
IS - 6
ER -