Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling

Varun Chokshi; Ming Gao; Bryce D. Grier; Ashley Owens; Hui Wang; Paul F. Worley; Hey Kyoung Lee

doi:10.1016/j.neuron.2019.08.017

Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling

Varun Chokshi, Ming Gao, Bryce D. Grier, Ashley Owens, Hui Wang, Paul F. Worley, Hey Kyoung Lee

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Chokshi et al. demonstrate that visual experience-induced expression of H1a and its interaction with mGluR5 selectively depress intracortical synapses in an NMDAR-dependent manner. Such metaplasticity may benefit in vivo circuit function by allowing input-specific homeostatic control.

Original language	English (US)
Pages (from-to)	736-748.e6
Journal	Neuron
Volume	104
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2019.08.017
State	Published - Nov 20 2019

Keywords

H1a
NMDA receptor
mGluR5
metabotropic glutamate receptor
metaplasticity
visual cortex

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2019.08.017

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title = "Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling",

abstract = "Chokshi et al. demonstrate that visual experience-induced expression of H1a and its interaction with mGluR5 selectively depress intracortical synapses in an NMDAR-dependent manner. Such metaplasticity may benefit in vivo circuit function by allowing input-specific homeostatic control.",

keywords = "H1a, NMDA receptor, mGluR5, metabotropic glutamate receptor, metaplasticity, visual cortex",

author = "Varun Chokshi and Ming Gao and Grier, {Bryce D.} and Ashley Owens and Hui Wang and Worley, {Paul F.} and Lee, {Hey Kyoung}",

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AU - Chokshi, Varun

AU - Gao, Ming

AU - Grier, Bryce D.

AU - Owens, Ashley

AU - Wang, Hui

AU - Worley, Paul F.

AU - Lee, Hey Kyoung

PY - 2019/11/20

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KW - NMDA receptor

KW - mGluR5

KW - metabotropic glutamate receptor

KW - metaplasticity

KW - visual cortex

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Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling

Abstract

Keywords

ASJC Scopus subject areas

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