Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling

Varun Chokshi, Ming Gao, Bryce D. Grier, Ashley Owens, Hui Wang, Paul F. Worley, Hey Kyoung Lee

Research output: Contribution to journalArticle

Abstract

Chokshi et al. demonstrate that visual experience-induced expression of H1a and its interaction with mGluR5 selectively depress intracortical synapses in an NMDAR-dependent manner. Such metaplasticity may benefit in vivo circuit function by allowing input-specific homeostatic control.

Original languageEnglish (US)
Pages (from-to)736-748.e6
JournalNeuron
Volume104
Issue number4
DOIs
StatePublished - Nov 20 2019

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Keywords

  • H1a
  • metabotropic glutamate receptor
  • metaplasticity
  • mGluR5
  • NMDA receptor
  • visual cortex

ASJC Scopus subject areas

  • Neuroscience(all)

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