Chokshi et al. demonstrate that visual experience-induced expression of H1a and its interaction with mGluR5 selectively depress intracortical synapses in an NMDAR-dependent manner. Such metaplasticity may benefit in vivo circuit function by allowing input-specific homeostatic control.
- metabotropic glutamate receptor
- NMDA receptor
- visual cortex
ASJC Scopus subject areas