Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission

C. D. Blackstone, S. Supattapone, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

In slices of adult rat cerebellum inositolphospholipid turnover is stimulated markedly by glutamate and its rigid analogues quisqualate and ibotenate. The drug and amino acid specificity of the responses reflects a quisqualate-preferring excitatory amino acid receptor. The absence of glutamate-enhanced inositolphospholipid turnover in mice with Purkinje-cell degeneration indicates that the inositolphospholipid-linked quisqualate receptor mediates parallel fiber-Purkinje cell synaptic transmission. The quantitative prominence of this synapse accounts for the massive enrichment of elements of the inositolphospholipid system in cerebellar Purkinje cells.

Original languageEnglish (US)
Pages (from-to)4316-4320
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number11
StatePublished - 1989

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Purkinje Cells
Glutamate Receptors
Synaptic Transmission
Quisqualic Acid
Glutamic Acid
AMPA Receptors
Synapses
Cerebellum
Amino Acids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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