Inositol pyrophosphates regulate endocytic trafficking

Adolfo Saiardi; Catherine Sciambi; J. Michael McCaffery; Beverly Wendland; Solomon H. Snyder

doi:10.1073/pnas.212527899

Inositol pyrophosphates regulate endocytic trafficking

Adolfo Saiardi, Catherine Sciambi, J. Michael McCaffery, Beverly Wendland, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article

Abstract

The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively associated with deficient formation of inositol pyrophosphates. We show that this phenotype reflects specific abnormalities in endocytic pathways and not other components of membrane trafficking. Thus, inositol pyrophosphates are major regulators of endocytosis.

Original language	English (US)
Pages (from-to)	14206-14211
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	99
Issue number	22
DOIs	https://doi.org/10.1073/pnas.212527899
State	Published - Oct 29 2002

ASJC Scopus subject areas

General

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Saiardi, A., Sciambi, C., McCaffery, J. M., Wendland, B., & Snyder, S. H. (2002). Inositol pyrophosphates regulate endocytic trafficking. Proceedings of the National Academy of Sciences of the United States of America, 99(22), 14206-14211. https://doi.org/10.1073/pnas.212527899

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AU - Snyder, Solomon H.

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