Abstract
The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively associated with deficient formation of inositol pyrophosphates. We show that this phenotype reflects specific abnormalities in endocytic pathways and not other components of membrane trafficking. Thus, inositol pyrophosphates are major regulators of endocytosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14206-14211 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 99 |
| Issue number | 22 |
| DOIs | |
| State | Published - Oct 29 2002 |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
Inositol pyrophosphates regulate endocytic trafficking. / Saiardi, Adolfo; Sciambi, Catherine; McCaffery, J. Michael; Wendland, Beverly; Snyder, Solomon H.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 22, 29.10.2002, p. 14206-14211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inositol pyrophosphates regulate endocytic trafficking
AU - Saiardi, Adolfo
AU - Sciambi, Catherine
AU - McCaffery, J. Michael
AU - Wendland, Beverly
AU - Snyder, Solomon H
PY - 2002/10/29
Y1 - 2002/10/29
N2 - The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively associated with deficient formation of inositol pyrophosphates. We show that this phenotype reflects specific abnormalities in endocytic pathways and not other components of membrane trafficking. Thus, inositol pyrophosphates are major regulators of endocytosis.
AB - The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively associated with deficient formation of inositol pyrophosphates. We show that this phenotype reflects specific abnormalities in endocytic pathways and not other components of membrane trafficking. Thus, inositol pyrophosphates are major regulators of endocytosis.
UR - http://www.scopus.com/inward/record.url?scp=0037195099&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037195099&partnerID=8YFLogxK
U2 - 10.1073/pnas.212527899
DO - 10.1073/pnas.212527899
M3 - Article
C2 - 12391334
AN - SCOPUS:0037195099
VL - 99
SP - 14206
EP - 14211
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 22
ER -