Inositol pyrophosphates regulate endocytic trafficking

Adolfo Saiardi, Catherine Sciambi, J. Michael McCaffery, Beverly Wendland, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

143 Scopus citations


The high energy potential and rapid turnover of the recently discovered inositol pyrophosphates, such as diphosphoinositol-pentakisphosphate and bis-diphosphoinositol-tetrakisphosphate, suggest a dynamic cellular role, but no specific functions have yet been established. Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic membrane defects selectively associated with deficient formation of inositol pyrophosphates. We show that this phenotype reflects specific abnormalities in endocytic pathways and not other components of membrane trafficking. Thus, inositol pyrophosphates are major regulators of endocytosis.

Original languageEnglish (US)
Pages (from-to)14206-14211
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number22
StatePublished - Oct 29 2002

ASJC Scopus subject areas

  • General


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