Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity

Adam C. Resnick, Adele M. Snowman, Bingnan M. Kang, K. Joseph Hurt, Solomon H. Snyder, Adolfo Saiardi

Research output: Contribution to journalArticle

Abstract

Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhiblted phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.

Original languageEnglish (US)
Pages (from-to)12783-12788
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number36
DOIs
StatePublished - Sep 6 2005

Keywords

  • Lipids
  • Nucleus
  • Wortmannin

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity'. Together they form a unique fingerprint.

  • Cite this