Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2

Susan M. Voglmaier, James H. Keen, Jo Ellen Murphy, Christopher D. Ferris, Glenn D. Prestwich, Solomon H. Snyder, Anne B. Theibert

Research output: Contribution to journalArticlepeer-review


To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of the α-subunit of the clathrin assembly protein AP-2. The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Aug 31 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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