Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2

Susan M. Voglmaier, James H. Keen, Jo Ellen Murphy, Christopher D. Ferris, Glenn D. Prestwich, Solomon H Snyder, Anne B. Theibert

Research output: Contribution to journalArticle

Abstract

To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of the α-subunit of the clathrin assembly protein AP-2. The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume187
Issue number1
DOIs
StatePublished - Aug 31 1992

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Vesicular Transport Adaptor Proteins
Adaptor Protein Complex Subunits
Phytic Acid
Proteins
Polyacrylamide Gel Electrophoresis
Amino Acid Sequence
Carrier Proteins
Nucleotides
Complementary DNA
Clone Cells
Genes
Amino Acids
Antibodies
inositol hexakisphosphate receptor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2. / Voglmaier, Susan M.; Keen, James H.; Murphy, Jo Ellen; Ferris, Christopher D.; Prestwich, Glenn D.; Snyder, Solomon H; Theibert, Anne B.

In: Biochemical and Biophysical Research Communications, Vol. 187, No. 1, 31.08.1992, p. 158-163.

Research output: Contribution to journalArticle

Voglmaier, Susan M. ; Keen, James H. ; Murphy, Jo Ellen ; Ferris, Christopher D. ; Prestwich, Glenn D. ; Snyder, Solomon H ; Theibert, Anne B. / Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2. In: Biochemical and Biophysical Research Communications. 1992 ; Vol. 187, No. 1. pp. 158-163.
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