Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis

Sarbani Ghoshal, Richa Tyagi, Qingzhang Zhu, Anutosh Chakraborty

Research output: Contribution to journalArticlepeer-review


Lipolysis leads to the breakdown of stored triglycerides (TAG) to release free fatty acids (FFA) and glycerol which is utilized by energy expenditure pathways to generate energy. Therefore, a decrease in lipolysis augments fat accumulation in adipocytes which promotes weight gain. Conversely, if lipolysis is not complemented by energy expenditure, it leads to FFA induced insulin resistance and type-2 diabetes. Thus, lipolysis is under stringent physiological regulation, although the precise mechanism of the regulation is not known. Deletion of inositol hexakisphosphate kinase-1 (IP6K1), the major inositol pyrophosphate biosynthetic enzyme, protects mice from high fat diet (HFD) induced obesity and insulin resistance. IP6K1-KO mice are lean due to enhanced energy expenditure. Therefore, IP6K1 is a target in obesity and type-2 diabetes. However, the mechanism/s by which IP6K1 regulates adipose tissue lipid metabolism is yet to be understood. Here, we demonstrate that IP6K1-KO mice display enhanced basal lipolysis. IP6K1 modulates lipolysis via its interaction with the lipolytic regulator protein perilipin1 (PLIN1). Furthermore, phosphorylation of IP6K1 at a PKC/PKA motif modulates its interaction with PLIN1 and lipolysis. Thus, IP6K1 is a novel regulator of PLIN1 mediated lipolysis.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalInternational Journal of Biochemistry and Cell Biology
StatePublished - Sep 1 2016


  • Diabetes
  • IP6K
  • Lipolysis
  • Obesity
  • Perilipin

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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