Inositol 1,3,4,5-tetrakisphosphate as a second messenger - A special role in neurones?

Robin F. Irvine, Tracy J. McNulty, Michael J. Schell

Research output: Contribution to journalArticle


There has been much controversy over the possibility that inositol 1,3,4,5-tetrakisphosphate (InsP4) may have a second messenger function. A possible resolution to this controversy may stem from the recent cloning of two putative receptors for InsP4, GAP1(IP4BP) and GAP1m. Both these proteins are expressed at high levels in neurones, as is inositol 1,4,5-trisphosphate 3-kinase, the enzyme that makes InsP4. In this review we discuss the possible relevance of these high expression levels to the complex way in which neurones control Ca2+ and use it as a second messenger. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalChemistry and Physics of Lipids
Issue number1-2
StatePublished - Apr 1 1999



  • Calcium
  • Inositol
  • Inositol 1,3,4,5-tetrakisphosphate
  • Neurone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology

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