Innovative strategies in living donor kidney transplantation

Research output: Contribution to journalArticle

Abstract

In an effort to increase living donor transplantation while minimizing risk and morbidity, recent advances have been made in surgical technique, kidney paired donation, desensitization, identification of living donors and research into living donor outcomes. Single-port nephrectomy and vaginal extraction have reduced donor nephrectomy incision size. Transport of live donor kidneys has reduced geographic barriers to kidney paired donation, and participation of compatible pairs and nondirected donors has increased match opportunities for incompatible pairs participating in this modality. ABO-incompatible transplantation can now be successfully performed without high-intensity immunomodulation, and HLA-incompatible transplantation has been shown in a large single-center study to provide profound survival benefit compared with waiting for a compatible donor. Complement inhibition is an exciting, emerging approach that may facilitate incompatible transplantation and treat antibody-mediated rejection. Educational and communications interventions are proving valuable in helping patients find living donors, and large studies continue to provide reassurance to carefully screened living donors that risks are very low. As living donors are critical to addressing the profound organ shortage, efforts to increase living donation remain important.

Original languageEnglish (US)
Pages (from-to)332-338
Number of pages7
JournalNature Reviews Nephrology
Volume8
Issue number6
DOIs
StatePublished - Jun 2012

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Living Donors
Kidney Transplantation
Transplantation
Tissue Donors
Nephrectomy
Kidney
Immunomodulation
Communication
Morbidity
Survival
Antibodies
Research

ASJC Scopus subject areas

  • Nephrology

Cite this

Innovative strategies in living donor kidney transplantation. / Segev, Dorry.

In: Nature Reviews Nephrology, Vol. 8, No. 6, 06.2012, p. 332-338.

Research output: Contribution to journalArticle

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