@inproceedings{5bad5f26f1fb4bcd8125d64818bbd27a,
title = "Innovative approach for in-vivo ablation validation on multimodal images",
abstract = "Radiofrequency ablation (RFA) is an important therapeutic procedure for small hepatic tumors. To make sure that the target tumor is effectively treated, RFA monitoring is essential. While several imaging modalities can observe the ablation procedure, it is not clear how ablated lesions on the images correspond to actual necroses. This uncertainty contributes to the high local recurrence rates (up to 55%) after radiofrequency ablative therapy. This study investigates a novel approach to correlate images of ablated lesions with actual necroses. We mapped both intraoperative images of the lesion and a slice through the actual necrosis in a common reference frame. An electromagnetic tracking system was used to accurately match lesion slices from different imaging modalities. To minimize the liver deformation effect, the tracking reference frame was defined inside the tissue by anchoring an electromagnetic sensor adjacent to the lesion. A validation test was performed using a phantom and proved that the end-to-end accuracy of the approach was within 2mm. In an in-vivo experiment, intraoperative magnetic resonance imaging (MRI) and ultrasound (US) ablation images were correlated to gross and histopathology. The results indicate that the proposed method can accurately correlate invivo ablations on different modalities. Ultimately, this will improve the interpretation of the ablation monitoring and reduce the recurrence rates associated with RFA.",
keywords = "Ablation Validation, Liver Surgery, Monitoring, Necrosis Correlation",
author = "O. Shahin and G. Karagkounis and D. Carnegie and A. Schlaefer and E. Boctor",
year = "2014",
doi = "10.1117/12.2041835",
language = "English (US)",
isbn = "9780819498298",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Medical Imaging 2014",
note = "Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling ; Conference date: 18-02-2014 Through 20-02-2014",
}