Innovations in Targeted Anti-Adhesion Treatment for Sickle Cell Disease

Julie Kanter, Sophie Lanzkron

Research output: Contribution to journalReview article

Abstract

Sickle cell disease (SCD) is an inherited hemoglobinopathy that leads to significant lifetime morbidity and early mortality. An enhanced understanding of the complex pathophysiology of the disease has elucidated novel therapeutic targets for which new therapies are in development. In order to increase the therapeutic landscape, it has been important to identify the blood vessel and more specifically the endothelium as the target organ in this complex disease. Through this lens, we present a review of new anti-adhesion therapies for SCD in development. The long-term promise of multimodal therapies for SCD is finally on the horizon.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalClinical pharmacology and therapeutics
Volume107
Issue number1
DOIs
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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