Innervation of human hippocampus by noradrenergic systems: Normal anatomy and structural abnormalities in aging and in Alzheimer's disease

R. E. Powers, R. G. Struble, M. F. Casanova, D. T. O'Connor, C. A. Kitt, D. L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

Immunocytochemical studies, using an antibody directed against human dopamine β-hydroxylase, identified an extensive plexus of noradrenergic axons/terminals in normal human hippocampus. In hippocampi of individuals with Alzheimer's disease, the density of noradrenergic innervation was reduced and abnormal noradrenergic axons, which exhibited multifocal enlargements, were present in the neuropil. Some of these neuntes were clustered around deposits of amyloid (senile plaques), and these abnormalities were most common in CA3-4, a region normally showing a relatively high density of noradrenergic terminals. This investigation provides direct evidence for structural abnormalities of noradrenergic axons/nerve terminals in hippocampi of individuals with Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)401-417
Number of pages17
JournalNeuroscience
Volume25
Issue number2
DOIs
StatePublished - May 1988

ASJC Scopus subject areas

  • Neuroscience(all)

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