Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

Vasiliki Koliaraki, Niki Chalkidi, Ana Henriques, Christos Tzaferis, Apostolos Polykratis, Ari Waisman, Werner Muller, David J. Hackam, Manolis Pasparakis, George Kollias

Research output: Contribution to journalArticlepeer-review

Abstract

Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apc min/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.

Original languageEnglish (US)
Pages (from-to)536-545.e4
JournalCell Reports
Volume26
Issue number3
DOIs
StatePublished - Jan 15 2019

Keywords

  • cancer-associated fibroblasts
  • innate immunity
  • tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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