Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apc min/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.
- cancer-associated fibroblasts
- innate immunity
- tumor microenvironment
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)