Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1

Maureen P. Martin, Ying Qi, Xiaojiang Gao, Eriko Yamada, Jeffrey N. Martin, Florencia Pereyra, Sara Colombo, Elizabeth E. Brown, W. Lesley Shupert, John Phair, James J. Goedert, Susan Buchbinder, Gregory D Kirk, Amalio Telenti, Mark Connors, Stephen J. O'Brien, Bruce D. Walker, Peter Parham, Steven G. Deeks, Daniel W. McVicarMary Carrington

Research output: Contribution to journalArticle

Abstract

Allotypes of the natural killer (NK) cell receptor KIR3DL1 vary in both NK cell expression patterns and inhibitory capacity upon binding to their ligands, HLA-B Bw4 molecules, present on target cells. Using a sample size of over 1,500 human immunodeficiency virus (HIV)+ individuals, we show that various distinct allelic combinations of the KIR3DL1 and HLA-B loci significantly and strongly influence both AIDS progression and plasma HIV RNA abundance in a consistent manner. These genetic data correlate very well with previously defined functional differences that distinguish KIR3DL1 allotypes. The various epistatic effects observed here for common, distinct KIR3DL1 and HLA-B Bw4 combinations are unprecedented with regard to any pair of genetic loci in human disease, and indicate that NK cells may have a critical role in the natural history of HIV infection.

Original languageEnglish (US)
Pages (from-to)733-740
Number of pages8
JournalNature Genetics
Volume39
Issue number6
DOIs
StatePublished - Jun 2007

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HLA-B Antigens
HIV-1
Natural Killer Cells
HIV
Natural Killer Cell Receptors
Genetic Loci
Virus Diseases
Natural History
Sample Size
Acquired Immunodeficiency Syndrome
RNA
Ligands
HLA-Bw4 antigen

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Martin, M. P., Qi, Y., Gao, X., Yamada, E., Martin, J. N., Pereyra, F., ... Carrington, M. (2007). Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nature Genetics, 39(6), 733-740. https://doi.org/10.1038/ng2035

Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. / Martin, Maureen P.; Qi, Ying; Gao, Xiaojiang; Yamada, Eriko; Martin, Jeffrey N.; Pereyra, Florencia; Colombo, Sara; Brown, Elizabeth E.; Shupert, W. Lesley; Phair, John; Goedert, James J.; Buchbinder, Susan; Kirk, Gregory D; Telenti, Amalio; Connors, Mark; O'Brien, Stephen J.; Walker, Bruce D.; Parham, Peter; Deeks, Steven G.; McVicar, Daniel W.; Carrington, Mary.

In: Nature Genetics, Vol. 39, No. 6, 06.2007, p. 733-740.

Research output: Contribution to journalArticle

Martin, MP, Qi, Y, Gao, X, Yamada, E, Martin, JN, Pereyra, F, Colombo, S, Brown, EE, Shupert, WL, Phair, J, Goedert, JJ, Buchbinder, S, Kirk, GD, Telenti, A, Connors, M, O'Brien, SJ, Walker, BD, Parham, P, Deeks, SG, McVicar, DW & Carrington, M 2007, 'Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1', Nature Genetics, vol. 39, no. 6, pp. 733-740. https://doi.org/10.1038/ng2035
Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nature Genetics. 2007 Jun;39(6):733-740. https://doi.org/10.1038/ng2035
Martin, Maureen P. ; Qi, Ying ; Gao, Xiaojiang ; Yamada, Eriko ; Martin, Jeffrey N. ; Pereyra, Florencia ; Colombo, Sara ; Brown, Elizabeth E. ; Shupert, W. Lesley ; Phair, John ; Goedert, James J. ; Buchbinder, Susan ; Kirk, Gregory D ; Telenti, Amalio ; Connors, Mark ; O'Brien, Stephen J. ; Walker, Bruce D. ; Parham, Peter ; Deeks, Steven G. ; McVicar, Daniel W. ; Carrington, Mary. / Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. In: Nature Genetics. 2007 ; Vol. 39, No. 6. pp. 733-740.
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