Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Hee Sun Choi; Taejoon Won; Xuezhou Hou; Guobao Chen; William Bracamonte-Baran; Monica V. Talor; Ivana Jurčová; Ondrej Szárszoi; Lenka Čurnova; Ilja Stříž; Jody E. Hooper; Vojtěch Melenovský; Daniela Čiháková

doi:10.1016/j.celrep.2020.02.040

Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Hee Sun Choi, Taejoon Won, Xuezhou Hou, Guobao Chen, William Bracamonte-Baran, Monica V. Talor, Ivana Jurčová, Ondrej Szárszoi, Lenka Čurnova, Ilja Stříž, Jody E. Hooper, Vojtěch Melenovský, Daniela Čiháková

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

Original language	English (US)
Pages (from-to)	2989-3003.e6
Journal	Cell Reports
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.02.040
State	Published - Mar 3 2020

Keywords

IL-33
Innate lymphoid cells
cardiac inflammation
eosinophils
group 2 innate lymphoid cells
mediastinum
pericarditis
serosal cavity

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2020.02.040

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Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. / Choi, Hee Sun; Won, Taejoon; Hou, Xuezhou; Chen, Guobao; Bracamonte-Baran, William; Talor, Monica V.; Jurčová, Ivana; Szárszoi, Ondrej; Čurnova, Lenka; Stříž, Ilja; Hooper, Jody E.; Melenovský, Vojtěch; Čiháková, Daniela.

In: Cell Reports, Vol. 30, No. 9, 03.03.2020, p. 2989-3003.e6.

Research output: Contribution to journal › Article › peer-review

Choi, Hee Sun ; Won, Taejoon ; Hou, Xuezhou ; Chen, Guobao ; Bracamonte-Baran, William ; Talor, Monica V. ; Jurčová, Ivana ; Szárszoi, Ondrej ; Čurnova, Lenka ; Stříž, Ilja ; Hooper, Jody E. ; Melenovský, Vojtěch ; Čiháková, Daniela. / Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. In: Cell Reports. 2020 ; Vol. 30, No. 9. pp. 2989-3003.e6.

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title = "Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis",

abstract = "Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.",

keywords = "IL-33, Innate lymphoid cells, cardiac inflammation, eosinophils, group 2 innate lymphoid cells, mediastinum, pericarditis, serosal cavity",

author = "Choi, {Hee Sun} and Taejoon Won and Xuezhou Hou and Guobao Chen and William Bracamonte-Baran and Talor, {Monica V.} and Ivana Jur{\v c}ov{\'a} and Ondrej Sz{\'a}rszoi and Lenka {\v C}urnova and Ilja St{\v r}{\'i}{\v z} and Hooper, {Jody E.} and Vojt{\v e}ch Melenovsk{\'y} and Daniela {\v C}ih{\'a}kov{\'a}",

note = "Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2?/?, IL-13?/? and IL-33cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute (R01HL118183 and R01HL136586), the American Heart Association AWRP Winter 2017 Grant-in-Aid (17GRNT33700274), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award (19TPA34910007) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship (16PRE31170040) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O'Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship (16POST31330012) and American Autoimmune-Related Diseases Association (AARDA) 2016 Young Investigator Award to W.B.-B. H.S.C. and T.W. performed the experiments and analyzed the data. X.H. G.C. W.B.-B. and M.V.T. performed the experiments. I.J. O.S. L.C. I.S. and V.M. obtained the human pericardial fluid and isolated cells. J.E.H. obtained the research autopsy samples of pericardial fluid. H.S.C. and D.C. conceived the main ideas, designed the experiments, interpreted the data and wrote the manuscript. D.C. acquired the funding. The authors declare no competing interests. Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2 −/− , IL-13 −/− and IL-33 cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute ( R01HL118183 and R01HL136586 ), the American Heart Association AWRP Winter 2017 Grant-in-Aid ( 17GRNT33700274 ), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award ( 19TPA34910007 ) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship ( 16PRE31170040 ) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O{\textquoteright}Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship ( 16POST31330012 ) and American Autoimmune-Related Diseases Association ( AARDA ) 2016 Young Investigator Award to W.B.-B. Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = mar,

day = "3",

doi = "10.1016/j.celrep.2020.02.040",

language = "English (US)",

volume = "30",

pages = "2989--3003.e6",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "9",

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TY - JOUR

T1 - Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

AU - Choi, Hee Sun

AU - Won, Taejoon

AU - Hou, Xuezhou

AU - Chen, Guobao

AU - Bracamonte-Baran, William

AU - Talor, Monica V.

AU - Jurčová, Ivana

AU - Szárszoi, Ondrej

AU - Čurnova, Lenka

AU - Stříž, Ilja

AU - Hooper, Jody E.

AU - Melenovský, Vojtěch

AU - Čiháková, Daniela

N1 - Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2?/?, IL-13?/? and IL-33cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute (R01HL118183 and R01HL136586), the American Heart Association AWRP Winter 2017 Grant-in-Aid (17GRNT33700274), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award (19TPA34910007) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship (16PRE31170040) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O'Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship (16POST31330012) and American Autoimmune-Related Diseases Association (AARDA) 2016 Young Investigator Award to W.B.-B. H.S.C. and T.W. performed the experiments and analyzed the data. X.H. G.C. W.B.-B. and M.V.T. performed the experiments. I.J. O.S. L.C. I.S. and V.M. obtained the human pericardial fluid and isolated cells. J.E.H. obtained the research autopsy samples of pericardial fluid. H.S.C. and D.C. conceived the main ideas, designed the experiments, interpreted the data and wrote the manuscript. D.C. acquired the funding. The authors declare no competing interests. Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2 −/− , IL-13 −/− and IL-33 cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute ( R01HL118183 and R01HL136586 ), the American Heart Association AWRP Winter 2017 Grant-in-Aid ( 17GRNT33700274 ), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award ( 19TPA34910007 ) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship ( 16PRE31170040 ) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O’Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship ( 16POST31330012 ) and American Autoimmune-Related Diseases Association ( AARDA ) 2016 Young Investigator Award to W.B.-B. Publisher Copyright: © 2020 The Authors

PY - 2020/3/3

Y1 - 2020/3/3

N2 - Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

AB - Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

KW - IL-33

KW - Innate lymphoid cells

KW - cardiac inflammation

KW - eosinophils

KW - group 2 innate lymphoid cells

KW - mediastinum

KW - pericarditis

KW - serosal cavity

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U2 - 10.1016/j.celrep.2020.02.040

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AN - SCOPUS:85080150988

VL - 30

SP - 2989-3003.e6

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 9

ER -

Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

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Keywords

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