Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.
- Innate lymphoid cells
- cardiac inflammation
- group 2 innate lymphoid cells
- serosal cavity
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)