Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Hee Sun Choi, Taejoon Won, Xuezhou Hou, Guobao Chen, William Bracamonte-Baran, Monica V. Talor, Ivana Jurčová, Ondrej Szárszoi, Lenka Čurnova, Ilja Stříž, Jody E. Hooper, Vojtěch Melenovský, Daniela Čiháková

Research output: Contribution to journalArticlepeer-review

Abstract

Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

Original languageEnglish (US)
Pages (from-to)2989-3003.e6
JournalCell Reports
Volume30
Issue number9
DOIs
StatePublished - Mar 3 2020

Keywords

  • IL-33
  • Innate lymphoid cells
  • cardiac inflammation
  • eosinophils
  • group 2 innate lymphoid cells
  • mediastinum
  • pericarditis
  • serosal cavity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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