@article{eb2c8cfbf3094b5180cfe51e49180ab6,
title = "Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis",
abstract = "Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.",
keywords = "IL-33, Innate lymphoid cells, cardiac inflammation, eosinophils, group 2 innate lymphoid cells, mediastinum, pericarditis, serosal cavity",
author = "Choi, {Hee Sun} and Taejoon Won and Xuezhou Hou and Guobao Chen and William Bracamonte-Baran and Talor, {Monica V.} and Ivana Jur{\v c}ov{\'a} and Ondrej Sz{\'a}rszoi and Lenka {\v C}urnova and Ilja St{\v r}{\'i}{\v z} and Hooper, {Jody E.} and Vojt{\v e}ch Melenovsk{\'y} and Daniela {\v C}ih{\'a}kov{\'a}",
note = "Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2?/?, IL-13?/? and IL-33cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute (R01HL118183 and R01HL136586), the American Heart Association AWRP Winter 2017 Grant-in-Aid (17GRNT33700274), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award (19TPA34910007) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship (16PRE31170040) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O'Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship (16POST31330012) and American Autoimmune-Related Diseases Association (AARDA) 2016 Young Investigator Award to W.B.-B. H.S.C. and T.W. performed the experiments and analyzed the data. X.H. G.C. W.B.-B. and M.V.T. performed the experiments. I.J. O.S. L.C. I.S. and V.M. obtained the human pericardial fluid and isolated cells. J.E.H. obtained the research autopsy samples of pericardial fluid. H.S.C. and D.C. conceived the main ideas, designed the experiments, interpreted the data and wrote the manuscript. D.C. acquired the funding. The authors declare no competing interests. Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2 −/− , IL-13 −/− and IL-33 cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute ( R01HL118183 and R01HL136586 ), the American Heart Association AWRP Winter 2017 Grant-in-Aid ( 17GRNT33700274 ), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award ( 19TPA34910007 ) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship ( 16PRE31170040 ) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O{\textquoteright}Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship ( 16POST31330012 ) and American Autoimmune-Related Diseases Association ( AARDA ) 2016 Young Investigator Award to W.B.-B. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = mar,
day = "3",
doi = "10.1016/j.celrep.2020.02.040",
language = "English (US)",
volume = "30",
pages = "2989--3003.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",
}