Abstract
Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.
Original language | English (US) |
---|---|
Pages (from-to) | 2989-3003.e6 |
Journal | Cell Reports |
Volume | 30 |
Issue number | 9 |
DOIs | |
State | Published - Mar 3 2020 |
Keywords
- IL-33
- Innate lymphoid cells
- cardiac inflammation
- eosinophils
- group 2 innate lymphoid cells
- mediastinum
- pericarditis
- serosal cavity
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Access to Document
Other files and links
Fingerprint
Dive into the research topics of 'Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. / Choi, Hee Sun; Won, Taejoon; Hou, Xuezhou; Chen, Guobao; Bracamonte-Baran, William; Talor, Monica V.; Jurčová, Ivana; Szárszoi, Ondrej; Čurnova, Lenka; Stříž, Ilja; Hooper, Jody E.; Melenovský, Vojtěch; Čiháková, Daniela.
In: Cell Reports, Vol. 30, No. 9, 03.03.2020, p. 2989-3003.e6.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis
AU - Choi, Hee Sun
AU - Won, Taejoon
AU - Hou, Xuezhou
AU - Chen, Guobao
AU - Bracamonte-Baran, William
AU - Talor, Monica V.
AU - Jurčová, Ivana
AU - Szárszoi, Ondrej
AU - Čurnova, Lenka
AU - Stříž, Ilja
AU - Hooper, Jody E.
AU - Melenovský, Vojtěch
AU - Čiháková, Daniela
N1 - Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2?/?, IL-13?/? and IL-33cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute (R01HL118183 and R01HL136586), the American Heart Association AWRP Winter 2017 Grant-in-Aid (17GRNT33700274), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award (19TPA34910007) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship (16PRE31170040) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O'Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship (16POST31330012) and American Autoimmune-Related Diseases Association (AARDA) 2016 Young Investigator Award to W.B.-B. H.S.C. and T.W. performed the experiments and analyzed the data. X.H. G.C. W.B.-B. and M.V.T. performed the experiments. I.J. O.S. L.C. I.S. and V.M. obtained the human pericardial fluid and isolated cells. J.E.H. obtained the research autopsy samples of pericardial fluid. H.S.C. and D.C. conceived the main ideas, designed the experiments, interpreted the data and wrote the manuscript. D.C. acquired the funding. The authors declare no competing interests. Funding Information: The authors would like to extend their gratitude to Jobert G. Barin, Nicola L. Diny, Megan K. Wood, David Hughes, Hannah Kalinoski, and Paul Delgado for insightful discussions; Megan K. Wood and Jiyeon Lee for manuscript editing; Dr. Andrew N.J. McKenzie (Medical Research Council, Cambridge, UK) for the ST2 −/− , IL-13 −/− and IL-33 cit/+ mice; Dr. James Lee (Mayo Clinic, Scottsdale, AZ, USA) for the IL-5Tg mice; Xiaoling Zhang (Johns Hopkins Ross Flow Cytometry Core) for cell sorting; Djahida Bedja and Nadan Wang for echocardiography; Kevin Brown (Fluidigm) for the CyTOF antibody panel design; Takuya Ohtani (Penn Institute for Immunology at the University of Pennsylvania) for operating CyTOF and acquiring samples; and the animal resources at Johns Hopkins University. This work was supported by grants from the National Institutes of Health/National Heart, Lung, and Blood Institute ( R01HL118183 and R01HL136586 ), the American Heart Association AWRP Winter 2017 Grant-in-Aid ( 17GRNT33700274 ), the Johns Hopkins 2015 Catalyst Award, and the American Heart Association 2019 Transformational Project Award ( 19TPA34910007 ) to D.C.; the Matthew Vernon Poyner (MVP) Memorial Myocarditis Research Fund to D.C. and Nisha Gilotra; the American Heart Association Predoctoral Fellowship ( 16PRE31170040 ) to H.S.C.; the Myocarditis Foundation 2018 Rhett Lundy Memorial Research Fellowship to T.W.; the Johns Hopkins Autoimmune Disease Research Center O’Leary-Wilson Fellowship, the Johns Hopkins Bloomberg School of Public Health Richard J. and Margaret Conn Himelfarb Student Support fund, and the Katherine E. Welsh Fellowship to X.H.; the Myocarditis Foundation 2016 Research Fellowship to G.C.; and the American Heart Association Postdoctoral Fellowship ( 16POST31330012 ) and American Autoimmune-Related Diseases Association ( AARDA ) 2016 Young Investigator Award to W.B.-B. Publisher Copyright: © 2020 The Authors
PY - 2020/3/3
Y1 - 2020/3/3
N2 - Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.
AB - Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.
KW - IL-33
KW - Innate lymphoid cells
KW - cardiac inflammation
KW - eosinophils
KW - group 2 innate lymphoid cells
KW - mediastinum
KW - pericarditis
KW - serosal cavity
UR - http://www.scopus.com/inward/record.url?scp=85080150988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85080150988&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2020.02.040
DO - 10.1016/j.celrep.2020.02.040
M3 - Article
C2 - 32130902
AN - SCOPUS:85080150988
VL - 30
SP - 2989-3003.e6
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 9
ER -