Abstract
The possibility that the natural antimicrobial properties of the cultured cells could be upregulated prior to transplantation was investigated. The main aim was to determine if cultured skin substitutes could be better prepared for abrupt transition from an aseptic environment to a contaminated wound site. The studies identified anti-microbial peptides that are made by epithelial cells including keratinocytes and these peptides are thought to be one component of innate immunity. The results suggest that it may be possible to enhance the innate immunity of cultured skin substitutes to better prepare them for survival in contaminated wounds.
| Original language | English (US) |
|---|---|
| Pages | 35 |
| Number of pages | 1 |
| State | Published - 2000 |
| Externally published | Yes |
| Event | Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling - York, United Kingdom Duration: Jul 16 2000 → Jul 19 2000 |
Other
| Other | Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell Signalling |
|---|---|
| Country/Territory | United Kingdom |
| City | York |
| Period | 7/16/00 → 7/19/00 |
ASJC Scopus subject areas
- General Engineering