Innate and acquired immunity and epithelial cell function in chronic rhinosinusitis.

R. P. Schleimer, Andrew P Lane, Jean Kim

Research output: Contribution to journalArticle

Abstract

We have outlined the myriad of roles, both proven and suspected, of epithelial cells in airway inflammation in general and CRS in particular. There is little doubt that these remarkable cells are essential for host defense, tissue responses to injury and threats, and inflammation that cause disease. We believe that many of these responses are likely to be amenable to the development of new therapies for CRS. As we acquire more information on the signaling processes that drive the protective responses in epithelial cells, we will improve our chances of developing approaches to enhance these responses without triggering deleterious inflammatory responses. Enhanced clearance of fungi and bacteria by local immune responses would likely be beneficial in reducing disease. As we better understand the signals that epithelial cells give and get from DCs, B and T lymphocytes, new opportunities for productive intervention will arise.

Original languageEnglish (US)
Pages (from-to)51-78
Number of pages28
JournalClinical allergy and immunology
Volume20
StatePublished - 2007
Externally publishedYes

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Adaptive Immunity
Innate Immunity
Epithelial Cells
Inflammation
B-Lymphocytes
Fungi
Bacteria
T-Lymphocytes
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Innate and acquired immunity and epithelial cell function in chronic rhinosinusitis. / Schleimer, R. P.; Lane, Andrew P; Kim, Jean.

In: Clinical allergy and immunology, Vol. 20, 2007, p. 51-78.

Research output: Contribution to journalArticle

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