Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

Kimberly E. Foreman, Jacques Friborg, Bala Chandran, Harutaka Katano, Tetsutaro Sata, Maria Mercader, Gary J. Nabel, Brian J. Nickoloff

Research output: Contribution to journalArticle

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) has been implicated in the development of Kaposi's sarcoma (KS) and several B-cell lymphoproliferative diseases. Serologic and molecular genetic association data has implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is morphologically and phenotypically consistent with KS, including the presence of angiogenesis and spindle-shaped cells latently infected with HHV-8. These findings suggest that HHV-8 is indeed the etiologic agent of KS, and that the virus plays an important role in initiation of this disease.

Original languageEnglish (US)
Pages (from-to)182-193
Number of pages12
JournalJournal of Dermatological Science
Volume26
Issue number3
DOIs
StatePublished - Jul 2001
Externally publishedYes

Keywords

  • AIDS
  • Angiogenesis
  • Animal model
  • Kaposi's sarcoma-associated herpesvirus
  • Viral pathogenesis

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Foreman, K. E., Friborg, J., Chandran, B., Katano, H., Sata, T., Mercader, M., Nabel, G. J., & Nickoloff, B. J. (2001). Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions. Journal of Dermatological Science, 26(3), 182-193. https://doi.org/10.1016/S0923-1811(01)00087-1