Initiation of homologous chromosome pairing during meiosis

Research output: Contribution to journalReview article

Abstract

Following pre-meiotic DNA replication, homologous chromosomes must be paired and become tightly linked to ensure reductional segregation during meiosis I. Therefore initiation of homologous chromosome pairing is vital for meiosis to proceed correctly. A number of factors contribute to the initiation of homologous chromosome pairing including telomere and centromere dynamics, pairing centres, checkpoint proteins and components of the axial element. The present review briefly summarizes recent progress in our understanding of initiation of homologous chromosome pairing during meiosis and discusses the differences that are observed between research organisms.

Original languageEnglish (US)
Pages (from-to)545-549
Number of pages5
JournalBiochemical Society transactions
Volume34
Issue number4
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

Keywords

  • Homologous chromosome pairing
  • Meiosis
  • Pairing centre
  • Recombination
  • Synapsis
  • Telomere bouquet

ASJC Scopus subject areas

  • Biochemistry

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