Initial plasma HIV-1 RNA levels and progression to AIDS in women and men

Timothy R. Sterling, David Vlahov, Jacquie Astemborski, Donald R. Hoover, Joseph Bernard Margolick, Thomas C Quinn

Research output: Contribution to journalArticle

Abstract

Background: It is unclear whether there are differences between men and women with human immunodeficiency virus type 1 (HIV-1) infection in the plasma level of viral RNA (the viral load). In men, the initial viral load after seroconversion predicts the likelihood of progression to the acquired immunodeficiency syndrome (AIDS), but the relation between the two has not been assessed in women. Currently, the guidelines for initiating antiretroviral therapy are applied uniformly to women and men. Methods: From 1988 through 1998, the viral load and the CD4+ lymphocyte count were measured approximately every six months in 156 male and 46 female injection-drug users who were followed prospectively after HIV-1 seroconversion. Results: The median initial viral load was 50,766 copies of HIV-1 RNA per milliliter in the men but only 15,103 copies per milliliter in the women (P

Original languageEnglish (US)
Pages (from-to)720-725
Number of pages6
JournalNew England Journal of Medicine
Volume344
Issue number10
DOIs
StatePublished - Mar 8 2001

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Viral Load
HIV-1
Acquired Immunodeficiency Syndrome
RNA
Viral RNA
Virus Diseases
CD4 Lymphocyte Count
Drug Users
Guidelines
Injections
Seroconversion
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Initial plasma HIV-1 RNA levels and progression to AIDS in women and men. / Sterling, Timothy R.; Vlahov, David; Astemborski, Jacquie; Hoover, Donald R.; Margolick, Joseph Bernard; Quinn, Thomas C.

In: New England Journal of Medicine, Vol. 344, No. 10, 08.03.2001, p. 720-725.

Research output: Contribution to journalArticle

Sterling, Timothy R. ; Vlahov, David ; Astemborski, Jacquie ; Hoover, Donald R. ; Margolick, Joseph Bernard ; Quinn, Thomas C. / Initial plasma HIV-1 RNA levels and progression to AIDS in women and men. In: New England Journal of Medicine. 2001 ; Vol. 344, No. 10. pp. 720-725.
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