TY - GEN
T1 - Initial investigations in applying a pilp-mineralization system to calcium oxalate formation using vapor diffusion
AU - Rodriguez, Douglas E.
AU - Khan, Saeed R.
AU - Gower, Laurie B.
PY - 2014
Y1 - 2014
N2 - In attempts to create an in vitro model system for studying the physiochemical mechanisms involved in the formation of kidney stones, the PILP mineralization process was employed. Here it is hypothesized that the acidic proteins present in urine and renal tissue play a central role in idiopathic nephrolithiasis, where non-classical crystallization may take place. In this two stage process, it has been proposed that calcium phosphate (CaP) is first deposited in the basement membrane of the renal tubules and then grows through the renal interstitium reaching the papillary surface to form sub-epithelial plaque called Randall's plaque (RP). The RP, once exposed to urine in the renal pelvis, becomes coated with calcium oxalate (CaOx) to form a stone. This work is the initial foray into determining the influence of a negatively charged polymer upon the formation of calcium oxalate.
AB - In attempts to create an in vitro model system for studying the physiochemical mechanisms involved in the formation of kidney stones, the PILP mineralization process was employed. Here it is hypothesized that the acidic proteins present in urine and renal tissue play a central role in idiopathic nephrolithiasis, where non-classical crystallization may take place. In this two stage process, it has been proposed that calcium phosphate (CaP) is first deposited in the basement membrane of the renal tubules and then grows through the renal interstitium reaching the papillary surface to form sub-epithelial plaque called Randall's plaque (RP). The RP, once exposed to urine in the renal pelvis, becomes coated with calcium oxalate (CaOx) to form a stone. This work is the initial foray into determining the influence of a negatively charged polymer upon the formation of calcium oxalate.
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M3 - Conference contribution
AN - SCOPUS:84897948981
SN - 9781118771396
VL - 247
T3 - Ceramic Transactions
SP - 65
EP - 74
BT - Ceramic Transactions
PB - American Ceramic Society
T2 - 10th Pacific Rim Conference on Ceramic and Glass Technology, PacRim 2013
Y2 - 2 June 2013 through 6 June 2013
ER -