Initial investigations in applying a pilp-mineralization system to calcium oxalate formation using vapor diffusion

Douglas E. Rodriguez, Saeed R. Khan, Laurie B. Gower

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In attempts to create an in vitro model system for studying the physiochemical mechanisms involved in the formation of kidney stones, the PILP mineralization process was employed. Here it is hypothesized that the acidic proteins present in urine and renal tissue play a central role in idiopathic nephrolithiasis, where non-classical crystallization may take place. In this two stage process, it has been proposed that calcium phosphate (CaP) is first deposited in the basement membrane of the renal tubules and then grows through the renal interstitium reaching the papillary surface to form sub-epithelial plaque called Randall's plaque (RP). The RP, once exposed to urine in the renal pelvis, becomes coated with calcium oxalate (CaOx) to form a stone. This work is the initial foray into determining the influence of a negatively charged polymer upon the formation of calcium oxalate.

Original languageEnglish (US)
Title of host publicationCeramic Transactions
PublisherAmerican Ceramic Society
Pages65-74
Number of pages10
Volume247
ISBN (Print)9781118771396
StatePublished - 2014
Externally publishedYes
Event10th Pacific Rim Conference on Ceramic and Glass Technology, PacRim 2013 - Coronado, CA, United States
Duration: Jun 2 2013Jun 6 2013

Publication series

NameCeramic Transactions
Volume247
ISSN (Print)10421122

Other

Other10th Pacific Rim Conference on Ceramic and Glass Technology, PacRim 2013
CountryUnited States
CityCoronado, CA
Period6/2/136/6/13

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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    Rodriguez, D. E., Khan, S. R., & Gower, L. B. (2014). Initial investigations in applying a pilp-mineralization system to calcium oxalate formation using vapor diffusion. In Ceramic Transactions (Vol. 247, pp. 65-74). (Ceramic Transactions; Vol. 247). American Ceramic Society.