Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11, 13, 14, and x

O. Colin Stine, Francis J. McMahon, Li Shiun Chen, Jianfeng Xu, Deborah A. Meyers, Dean F Mackinnon, Sylvia Simpson, Melvin G. McInnis, John P. Rice, Alison Goate, Theodore Reich, Howard J. Edenberg, Tatiana Foroud, John I. Nurnberger, Sevilla D. Detera-Wadleigh, Lynn R. Goldin, Juliet Guroff, Elliot S. Gershon, Mary C. Blehar, J Raymond Depaulo

Research output: Contribution to journalArticle

Abstract

We report on an initial genome screen of 540 individuals from 97 families collected as part of the NIMH Genetics Initiative Bipolar Group. Among the individuals studied, 232 were diagnosed with bipolar (BP) I, 72 with BPII, 88 with major depressive disorder recurrent type (UPR), and 32 with schizoaffective disorder, bipolar type (SA/BP). A total of 53 markers on chromosomes 2, 11, 13, 14, and X (average spacing: 11.5 cM) were studied at Johns Hopkins University. Tests for linkage were performed using nonparametric affected sib-pair and whole pedigree methods with three definitions of affected status. Three regions of interest were identified (13q14-32, Xp22, and Xq26-28). On chromosomes 2, 11, and 14, a disease locus with relative risk λ(i) = 1.5 could be excluded in

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume74
Issue number3
DOIs
StatePublished - 1997

Fingerprint

National Institute of Mental Health (U.S.)
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
Pedigree
Bipolar Disorder
Genome
Chromosomes, Human, Pair 14
Major Depressive Disorder
Psychotic Disorders

Keywords

  • Affective disorder
  • Linkage
  • Occlusion mapping

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees : Chromosomes 2, 11, 13, 14, and x. / Stine, O. Colin; McMahon, Francis J.; Chen, Li Shiun; Xu, Jianfeng; Meyers, Deborah A.; Mackinnon, Dean F; Simpson, Sylvia; McInnis, Melvin G.; Rice, John P.; Goate, Alison; Reich, Theodore; Edenberg, Howard J.; Foroud, Tatiana; Nurnberger, John I.; Detera-Wadleigh, Sevilla D.; Goldin, Lynn R.; Guroff, Juliet; Gershon, Elliot S.; Blehar, Mary C.; Depaulo, J Raymond.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 74, No. 3, 1997, p. 263-269.

Research output: Contribution to journalArticle

Stine, OC, McMahon, FJ, Chen, LS, Xu, J, Meyers, DA, Mackinnon, DF, Simpson, S, McInnis, MG, Rice, JP, Goate, A, Reich, T, Edenberg, HJ, Foroud, T, Nurnberger, JI, Detera-Wadleigh, SD, Goldin, LR, Guroff, J, Gershon, ES, Blehar, MC & Depaulo, JR 1997, 'Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11, 13, 14, and x', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 74, no. 3, pp. 263-269. https://doi.org/10.1002/(SICI)1096-8628(19970531)74:3<263::AID-AJMG5>3.0.CO;2-R
Stine, O. Colin ; McMahon, Francis J. ; Chen, Li Shiun ; Xu, Jianfeng ; Meyers, Deborah A. ; Mackinnon, Dean F ; Simpson, Sylvia ; McInnis, Melvin G. ; Rice, John P. ; Goate, Alison ; Reich, Theodore ; Edenberg, Howard J. ; Foroud, Tatiana ; Nurnberger, John I. ; Detera-Wadleigh, Sevilla D. ; Goldin, Lynn R. ; Guroff, Juliet ; Gershon, Elliot S. ; Blehar, Mary C. ; Depaulo, J Raymond. / Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees : Chromosomes 2, 11, 13, 14, and x. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1997 ; Vol. 74, No. 3. pp. 263-269.
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