Initial experience with a novel heat-exchanging catheter in neurosurgical patients

Anthony G. Doufas, Ozan Akça, Atul Barry, David A. Petrusca, Mohammad Irfan Suleman, Nobutada Morioka, John J. Guarnaschelli, Daniel I. Sessler

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Even mild hypothermia provides marked protection against cerebral ischemia in animal models. Hypothermia may be of therapeutic value during neurosurgical procedures. However, current cooling systems often fail to induce sufficient hypothermia before the dura is opened. Furthermore, they usually fail to restore normothermia by the end of surgery, thus delaying extubation. We evaluated a new internal heat-exchanging catheter. Eight ASA physical status II-IV patients (29-72 yr) undergoing craniotomy were enrolled. After the induction of general anesthesia, we introduced the SetPoint® catheter into the inferior vena cava via a femoral vein. The target core body temperature was 34°C-34.5°C. After reaching the target, core temperature was maintained until the dura was closed. Target core temperature was then set to 37.0°C, and the patient was rewarmed as quickly as possible. Seven patients had a tumor resection, and one had an aneurysm clipped. The core-cooling rate was 3.9°C ± 1.6°C/h, and the rewarming rate was 2.0°C ± 0.5°C/h; core temperature was 35.9°C ± 0.2°C by the end of surgery. Patients were subsequently kept normothermic for 3 h before the catheter was removed. No thrombus or other particulate material was identified on the extracted catheters. None of the patients suffered any complications that could be attributed to the SetPoint® system or thermal management.

Original languageEnglish (US)
Pages (from-to)1752-1756
Number of pages5
JournalAnesthesia and analgesia
Issue number6
StatePublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Initial experience with a novel heat-exchanging catheter in neurosurgical patients'. Together they form a unique fingerprint.

Cite this