TY - JOUR
T1 - Inhibitory synaptic interactions between cochlear nuclei
T2 - Evidence from an in vitro whole brain study
AU - Babalian, Alexander L.
AU - Ryugo, David K.
AU - Vischer, Mattheus W.
AU - Rouiller, Eric M.
PY - 1999/6/23
Y1 - 1999/6/23
N2 - Using guinea-pig isolated whole brain preparation in vitro, synaptic responses to electrical stimulation of auditory nerves were examined in intracellularly recorded and stained neurons of posteroventral and dorsal divisions of the cochlear nucleus. Stimulation of the contralateral auditory nerve evoked exclusively IPSPs in 70% of neurons, With amplitude of 2.3 ± 1.2 mV. Neurons of all major cell types were inhibited from the contralateral side. In the majority of responding cells (78%) IPSPs were induced at latencies of 39 ms suggesting di- and trisynaptic connections from contralateral auditory afferents or, respectively, mono-and disynaptic connections from the contralateral cochlear nucleus. Few cells responded with long-latency IPSPs (13.5-23 ms), indicating involvement of polysynaptic pathways. These data demonstrate the existence of functional, direct and indirect inhibitory connections between the cochlear nuclei.
AB - Using guinea-pig isolated whole brain preparation in vitro, synaptic responses to electrical stimulation of auditory nerves were examined in intracellularly recorded and stained neurons of posteroventral and dorsal divisions of the cochlear nucleus. Stimulation of the contralateral auditory nerve evoked exclusively IPSPs in 70% of neurons, With amplitude of 2.3 ± 1.2 mV. Neurons of all major cell types were inhibited from the contralateral side. In the majority of responding cells (78%) IPSPs were induced at latencies of 39 ms suggesting di- and trisynaptic connections from contralateral auditory afferents or, respectively, mono-and disynaptic connections from the contralateral cochlear nucleus. Few cells responded with long-latency IPSPs (13.5-23 ms), indicating involvement of polysynaptic pathways. These data demonstrate the existence of functional, direct and indirect inhibitory connections between the cochlear nuclei.
KW - Cochlear nucleus
KW - EPSP
KW - IPSP
KW - Intracellular recording and staining
KW - Isolated whole brain
KW - Synaptic potentials
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U2 - 10.1097/00001756-199906230-00022
DO - 10.1097/00001756-199906230-00022
M3 - Article
C2 - 10501532
AN - SCOPUS:0033597578
SN - 0959-4965
VL - 10
SP - 1913
EP - 1917
JO - Neuroreport
JF - Neuroreport
IS - 9
ER -