Inhibitory interactions between BK and JC virus among kidney transplant recipients

Xingxing S. Cheng, Daniel L. Bohl, Gregory A. Storch, Caroline Ryschkewitsch, Monique Gaudreault-Keener, Eugene O. Major, Parmjeet Randhawa, Karen L. Hardinger, Daniel Brennan

Research output: Contribution to journalArticle

Abstract

BK and JC polyomaviruses can reactivate after transplantation, causing renal dysfunction and graft loss. The incidence of JC reactivation after renal transplant is not well understood. Here, we characterized JC reactivation using samples collected during the first year after transplantation from 200 kidney recipients. We detected BK and JC viruses in the urine of 35 and 16% of transplant recipients, respectively. The median viral load in the urine was 400 times higher for BK virus than JC virus. The presence of BK viruria made concurrent JC viruria less likely: JC viruria was detected in 22% of non-BK viruric recipients compared with 4% of BK viruric recipients (P = 0.001). The codetection rate was 1.5%, which is less than the expected 5.6% if reactivation of each virus was independent (P = 0.001). We did not observe JC viremia, JC nephropathy, or progressive multifocal leukoencephalopathy. The onset of JC viruria was associated with donor, but not recipient, JC-specific antibody in a titer-dependent fashion and inversely associated with donor and recipient BK-specific antibody. Donor and recipient JC seropositivity did not predict BK viruria or viremia. In conclusion, among renal transplant recipients, infection with one polyomavirus inversely associates with infection with the other.

Original languageEnglish (US)
Pages (from-to)825-831
Number of pages7
JournalJournal of the American Society of Nephrology
Volume22
Issue number5
DOIs
StatePublished - May 1 2011
Externally publishedYes

Fingerprint

BK Virus
JC Virus
Viremia
Tissue Donors
Kidney
Kidney Transplantation
Urine
Progressive Multifocal Leukoencephalopathy
Transplants
Polyomavirus
Antibodies
Infection
Viral Load
Viruses
Incidence
Transplant Recipients

ASJC Scopus subject areas

  • Nephrology

Cite this

Cheng, X. S., Bohl, D. L., Storch, G. A., Ryschkewitsch, C., Gaudreault-Keener, M., Major, E. O., ... Brennan, D. (2011). Inhibitory interactions between BK and JC virus among kidney transplant recipients. Journal of the American Society of Nephrology, 22(5), 825-831. https://doi.org/10.1681/ASN.2010080877

Inhibitory interactions between BK and JC virus among kidney transplant recipients. / Cheng, Xingxing S.; Bohl, Daniel L.; Storch, Gregory A.; Ryschkewitsch, Caroline; Gaudreault-Keener, Monique; Major, Eugene O.; Randhawa, Parmjeet; Hardinger, Karen L.; Brennan, Daniel.

In: Journal of the American Society of Nephrology, Vol. 22, No. 5, 01.05.2011, p. 825-831.

Research output: Contribution to journalArticle

Cheng, XS, Bohl, DL, Storch, GA, Ryschkewitsch, C, Gaudreault-Keener, M, Major, EO, Randhawa, P, Hardinger, KL & Brennan, D 2011, 'Inhibitory interactions between BK and JC virus among kidney transplant recipients', Journal of the American Society of Nephrology, vol. 22, no. 5, pp. 825-831. https://doi.org/10.1681/ASN.2010080877
Cheng XS, Bohl DL, Storch GA, Ryschkewitsch C, Gaudreault-Keener M, Major EO et al. Inhibitory interactions between BK and JC virus among kidney transplant recipients. Journal of the American Society of Nephrology. 2011 May 1;22(5):825-831. https://doi.org/10.1681/ASN.2010080877
Cheng, Xingxing S. ; Bohl, Daniel L. ; Storch, Gregory A. ; Ryschkewitsch, Caroline ; Gaudreault-Keener, Monique ; Major, Eugene O. ; Randhawa, Parmjeet ; Hardinger, Karen L. ; Brennan, Daniel. / Inhibitory interactions between BK and JC virus among kidney transplant recipients. In: Journal of the American Society of Nephrology. 2011 ; Vol. 22, No. 5. pp. 825-831.
@article{1957f431e1c84e68983d29836dad5d63,
title = "Inhibitory interactions between BK and JC virus among kidney transplant recipients",
abstract = "BK and JC polyomaviruses can reactivate after transplantation, causing renal dysfunction and graft loss. The incidence of JC reactivation after renal transplant is not well understood. Here, we characterized JC reactivation using samples collected during the first year after transplantation from 200 kidney recipients. We detected BK and JC viruses in the urine of 35 and 16{\%} of transplant recipients, respectively. The median viral load in the urine was 400 times higher for BK virus than JC virus. The presence of BK viruria made concurrent JC viruria less likely: JC viruria was detected in 22{\%} of non-BK viruric recipients compared with 4{\%} of BK viruric recipients (P = 0.001). The codetection rate was 1.5{\%}, which is less than the expected 5.6{\%} if reactivation of each virus was independent (P = 0.001). We did not observe JC viremia, JC nephropathy, or progressive multifocal leukoencephalopathy. The onset of JC viruria was associated with donor, but not recipient, JC-specific antibody in a titer-dependent fashion and inversely associated with donor and recipient BK-specific antibody. Donor and recipient JC seropositivity did not predict BK viruria or viremia. In conclusion, among renal transplant recipients, infection with one polyomavirus inversely associates with infection with the other.",
author = "Cheng, {Xingxing S.} and Bohl, {Daniel L.} and Storch, {Gregory A.} and Caroline Ryschkewitsch and Monique Gaudreault-Keener and Major, {Eugene O.} and Parmjeet Randhawa and Hardinger, {Karen L.} and Daniel Brennan",
year = "2011",
month = "5",
day = "1",
doi = "10.1681/ASN.2010080877",
language = "English (US)",
volume = "22",
pages = "825--831",
journal = "Journal of the American Society of Nephrology : JASN",
issn = "1046-6673",
publisher = "American Society of Nephrology",
number = "5",

}

TY - JOUR

T1 - Inhibitory interactions between BK and JC virus among kidney transplant recipients

AU - Cheng, Xingxing S.

AU - Bohl, Daniel L.

AU - Storch, Gregory A.

AU - Ryschkewitsch, Caroline

AU - Gaudreault-Keener, Monique

AU - Major, Eugene O.

AU - Randhawa, Parmjeet

AU - Hardinger, Karen L.

AU - Brennan, Daniel

PY - 2011/5/1

Y1 - 2011/5/1

N2 - BK and JC polyomaviruses can reactivate after transplantation, causing renal dysfunction and graft loss. The incidence of JC reactivation after renal transplant is not well understood. Here, we characterized JC reactivation using samples collected during the first year after transplantation from 200 kidney recipients. We detected BK and JC viruses in the urine of 35 and 16% of transplant recipients, respectively. The median viral load in the urine was 400 times higher for BK virus than JC virus. The presence of BK viruria made concurrent JC viruria less likely: JC viruria was detected in 22% of non-BK viruric recipients compared with 4% of BK viruric recipients (P = 0.001). The codetection rate was 1.5%, which is less than the expected 5.6% if reactivation of each virus was independent (P = 0.001). We did not observe JC viremia, JC nephropathy, or progressive multifocal leukoencephalopathy. The onset of JC viruria was associated with donor, but not recipient, JC-specific antibody in a titer-dependent fashion and inversely associated with donor and recipient BK-specific antibody. Donor and recipient JC seropositivity did not predict BK viruria or viremia. In conclusion, among renal transplant recipients, infection with one polyomavirus inversely associates with infection with the other.

AB - BK and JC polyomaviruses can reactivate after transplantation, causing renal dysfunction and graft loss. The incidence of JC reactivation after renal transplant is not well understood. Here, we characterized JC reactivation using samples collected during the first year after transplantation from 200 kidney recipients. We detected BK and JC viruses in the urine of 35 and 16% of transplant recipients, respectively. The median viral load in the urine was 400 times higher for BK virus than JC virus. The presence of BK viruria made concurrent JC viruria less likely: JC viruria was detected in 22% of non-BK viruric recipients compared with 4% of BK viruric recipients (P = 0.001). The codetection rate was 1.5%, which is less than the expected 5.6% if reactivation of each virus was independent (P = 0.001). We did not observe JC viremia, JC nephropathy, or progressive multifocal leukoencephalopathy. The onset of JC viruria was associated with donor, but not recipient, JC-specific antibody in a titer-dependent fashion and inversely associated with donor and recipient BK-specific antibody. Donor and recipient JC seropositivity did not predict BK viruria or viremia. In conclusion, among renal transplant recipients, infection with one polyomavirus inversely associates with infection with the other.

UR - http://www.scopus.com/inward/record.url?scp=79955601043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955601043&partnerID=8YFLogxK

U2 - 10.1681/ASN.2010080877

DO - 10.1681/ASN.2010080877

M3 - Article

VL - 22

SP - 825

EP - 831

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

SN - 1046-6673

IS - 5

ER -