Inhibitory effect of white wine on gastric myoelectrical activity and the role of vagal tone

D. Levanon, B. Goss, Jiande D.Z. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Although extensively investigated throughout the gastrointestinal tract, the influence of alcohol on gastric motility is still unclear. Our aim was to investigate the effect of wine on gastric myoelectrical activity and vagal activity. Ten healthy subjects were studied in two sessions with the electrogastrogram (EGG) for 30 min at baseline, 30 min after ingesting the test liquid [white wine (12.5% alcohol) or matched juice], and 60 min after a standard test meal. Spectral analysis was performed to compute EGG parameters and their postprandial changes. The vagal activity was assessed based on spectral analysis of the heart rate variability (HRV) signal derived from the ECG recording. White wine preload significantly diminished the postprandial increase in EGG dominant power compared to juice preload (1.16 ± 1.57 vs 5.48 ± 1.01 dB, P < 0.001). A significant decrease in vagal activity was observed after wine (23.40 ± 4.30 vs 17.43 ± 3.40%, P < 0.005), which remained unchanged after the test meal (23.40 ± 4.30 vs 16.77 ± 4.40%, P < 0.05). This decrease was not noted in the juice session. A correlation was established between changes after wine consumption in EGG dominant power and in the percentage of the vagal activity (r = 0.89, P < 0.05). In conclusion, white wine preload inhibits the postprandial EGG dominant power, suggesting a possible inhibition of postprandial gastric contractions. This effect may be associated with diminished vagal activity.

Original languageEnglish (US)
Article number455110
Pages (from-to)2500-2505
Number of pages6
JournalDigestive diseases and sciences
Volume47
Issue number11
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Alcohol
  • Electrogastrography
  • Gastric slow wave
  • Gastrointestinal motility
  • Heart rate variability
  • Stomach

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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