Inhibitory effect of subthreshold high-frequency stimuli: A computer simulation study

J. F. Saiz, J. M. Ferrero, F. J. Chorro, M. Monserrat, V. Lopez-Merino, J. M. Ferrero, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A computer model of the ventricular action potential was used to study the effect of trains of subthreshold high-frequency stimuli (TSc) on the prolongation of the effective refractory period (ERP). A zone of ventricular tissue is simulated by a one-dimensional structure. Trains of subthreshold high-frequency stimuli, at different frequencies were applied between the two suprathreshold pulses S1 and S2 and the ERP was measured as a function of TSc frequency. Our simulation results are in agreement with the experimental results. The results suggest that the prolongation of recovery from inactivation of the fast Na+ current could be partially responsible for the prolongation of the ERP.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages213-215
Number of pages3
Volume1
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
Duration: Oct 30 1997Nov 2 1997

Other

OtherProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityChicago, IL, USA
Period10/30/9711/2/97

Fingerprint

Refractory materials
Computer simulation
Tissue
Recovery

ASJC Scopus subject areas

  • Bioengineering

Cite this

Saiz, J. F., Ferrero, J. M., Chorro, F. J., Monserrat, M., Lopez-Merino, V., Ferrero, J. M., & Thakor, N. V. (1997). Inhibitory effect of subthreshold high-frequency stimuli: A computer simulation study. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 213-215). IEEE.

Inhibitory effect of subthreshold high-frequency stimuli : A computer simulation study. / Saiz, J. F.; Ferrero, J. M.; Chorro, F. J.; Monserrat, M.; Lopez-Merino, V.; Ferrero, J. M.; Thakor, Nitish V.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1997. p. 213-215.

Research output: Chapter in Book/Report/Conference proceedingChapter

Saiz, JF, Ferrero, JM, Chorro, FJ, Monserrat, M, Lopez-Merino, V, Ferrero, JM & Thakor, NV 1997, Inhibitory effect of subthreshold high-frequency stimuli: A computer simulation study. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, IEEE, pp. 213-215, Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Chicago, IL, USA, 10/30/97.
Saiz JF, Ferrero JM, Chorro FJ, Monserrat M, Lopez-Merino V, Ferrero JM et al. Inhibitory effect of subthreshold high-frequency stimuli: A computer simulation study. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1. IEEE. 1997. p. 213-215
Saiz, J. F. ; Ferrero, J. M. ; Chorro, F. J. ; Monserrat, M. ; Lopez-Merino, V. ; Ferrero, J. M. ; Thakor, Nitish V. / Inhibitory effect of subthreshold high-frequency stimuli : A computer simulation study. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 1 IEEE, 1997. pp. 213-215
@inbook{a3838f88066e49178c4e0943230ffbf0,
title = "Inhibitory effect of subthreshold high-frequency stimuli: A computer simulation study",
abstract = "A computer model of the ventricular action potential was used to study the effect of trains of subthreshold high-frequency stimuli (TSc) on the prolongation of the effective refractory period (ERP). A zone of ventricular tissue is simulated by a one-dimensional structure. Trains of subthreshold high-frequency stimuli, at different frequencies were applied between the two suprathreshold pulses S1 and S2 and the ERP was measured as a function of TSc frequency. Our simulation results are in agreement with the experimental results. The results suggest that the prolongation of recovery from inactivation of the fast Na+ current could be partially responsible for the prolongation of the ERP.",
author = "Saiz, {J. F.} and Ferrero, {J. M.} and Chorro, {F. J.} and M. Monserrat and V. Lopez-Merino and Ferrero, {J. M.} and Thakor, {Nitish V}",
year = "1997",
language = "English (US)",
volume = "1",
pages = "213--215",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",

}

TY - CHAP

T1 - Inhibitory effect of subthreshold high-frequency stimuli

T2 - A computer simulation study

AU - Saiz, J. F.

AU - Ferrero, J. M.

AU - Chorro, F. J.

AU - Monserrat, M.

AU - Lopez-Merino, V.

AU - Ferrero, J. M.

AU - Thakor, Nitish V

PY - 1997

Y1 - 1997

N2 - A computer model of the ventricular action potential was used to study the effect of trains of subthreshold high-frequency stimuli (TSc) on the prolongation of the effective refractory period (ERP). A zone of ventricular tissue is simulated by a one-dimensional structure. Trains of subthreshold high-frequency stimuli, at different frequencies were applied between the two suprathreshold pulses S1 and S2 and the ERP was measured as a function of TSc frequency. Our simulation results are in agreement with the experimental results. The results suggest that the prolongation of recovery from inactivation of the fast Na+ current could be partially responsible for the prolongation of the ERP.

AB - A computer model of the ventricular action potential was used to study the effect of trains of subthreshold high-frequency stimuli (TSc) on the prolongation of the effective refractory period (ERP). A zone of ventricular tissue is simulated by a one-dimensional structure. Trains of subthreshold high-frequency stimuli, at different frequencies were applied between the two suprathreshold pulses S1 and S2 and the ERP was measured as a function of TSc frequency. Our simulation results are in agreement with the experimental results. The results suggest that the prolongation of recovery from inactivation of the fast Na+ current could be partially responsible for the prolongation of the ERP.

UR - http://www.scopus.com/inward/record.url?scp=0031294157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031294157&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:0031294157

VL - 1

SP - 213

EP - 215

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

PB - IEEE

ER -