Inhibitory effect of subthreshold high-frequency stimuli: A computer simulation study

J. F. Saiz, J. M. Ferrero, F. J. Chorro, M. Monserrat, V. Lopez-Merino, J. M. Ferrero, N. V. Thakor

Research output: Contribution to journalConference article

Abstract

A computer model of the ventricular action potential was used to study the effect of trains of subthreshold high-frequency stimuli (TSc) on the prolongation of the effective refractory period (ERP). A zone of ventricular tissue is simulated by a one-dimensional structure. Trains of subthreshold high-frequency stimuli, at different frequencies were applied between the two suprathreshold pulses S1 and S2 and the ERP was measured as a function of TSc frequency. Our simulation results are in agreement with the experimental results. The results suggest that the prolongation of recovery from inactivation of the fast Na+ current could be partially responsible for the prolongation of the ERP.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - 1997
Externally publishedYes
EventProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
Duration: Oct 30 1997Nov 2 1997

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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