Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

Jie Zhang; Valina L. Dawson; Ted M. Dawson; Solomon H. Snyder

doi:10.1016/S0734-9750(97)88683-1

Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

Jie Zhang, Valina L. Dawson, Ted M. Dawson, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.

Original language	English (US)
Pages (from-to)	771
Number of pages	1
Journal	Biotechnology Advances
Volume	15
Issue number	3-4
DOIs	https://doi.org/10.1016/S0734-9750(97)88683-1
State	Published - 1997

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1016/S0734-9750(97)88683-1

Cite this

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title = "Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity",

abstract = "Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.",

author = "Jie Zhang and Dawson, {Valina L.} and Dawson, {Ted M.} and Snyder, {Solomon H.}",

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AU - Snyder, Solomon H.

PY - 1997

Y1 - 1997

N2 - Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.

AB - Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.

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Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

Abstract

ASJC Scopus subject areas

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