Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

Jie Zhang; Valina L. Dawson; Ted M. Dawson; Solomon H. Snyder

doi:10.1016/S0734-9750(97)88683-1

Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity

Jie Zhang, Valina L. Dawson, Ted M. Dawson, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.

Original language	English (US)
Number of pages	1
Journal	Biotechnology Advances
Volume	15
Issue number	3-4
DOIs	https://doi.org/10.1016/S0734-9750(97)88683-1
State	Published - Jan 1 1997

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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abstract = "Inhibitors of poly(ADP-ribose) synthetase can be used to prevent neurotoxicity mediated through N-methyl-D-aspartate (NMDA) receptors. Poly(ADP-ribose) synthetase inhibitors can be used therapeutically in the treatment of vascular stroke and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and Huntington's disease.",

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