@inproceedings{ed6ecc98e4554841bd3f86bf6032edf1,
title = "Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation. A Perfect Combination for Cancer Therapy.",
abstract = "Epigenetic silencing and inappropriate activation of gene expression are frequent events during the initiation and progression of cancer. These events involve a complex interplay between the hypermethylation of CpG dinucleotides within gene promoter and enhancer regions, the recruitment of transcriptional corepressors and the deacetylation and/or methylation of histone tails. These epigenetic regulators act in concert to block transcription or interfere with the maintenance of chromatin boundary regions. However, DNA/histone methylation and histone acetylation states are reversible, enzyme-mediated processes and as such, have emerged as promising targets for cancer therapy. This review will focus on the potential benefits and synergistic/additive effects of combining DNA-demethylating agents and histone deacetylase inhibitors or lysine-specific demethylase inhibitors together in epigenetic therapy for solid tumors and will highlight what is known regarding the mechanisms of action that contribute to the antitumor response.",
keywords = "DNA methyltransferase inhibitors, Drug synergy, Epigenetic therapy, Histone deacetylation and methylation inhibitors, Solid tumors",
author = "Zahnow, {C. A.} and M. Topper and M. Stone and T. Murray-Stewart and H. Li and Baylin, {S. B.} and Casero, {R. A.}",
note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
doi = "10.1016/bs.acr.2016.01.007",
language = "English (US)",
isbn = "9780128047897",
series = "Advances in Cancer Research",
publisher = "Academic Press Inc.",
pages = "55--111",
editor = "Fisher, {Paul B.} and Tew, {Kenneth D.}",
booktitle = "Advances in Cancer Research, 2016",
}