Inhibition of Zika virus by Wolbachia in Aedes aegypti

Eric Caragata, Heverton Leandro Carneiro Dutra, Luciano Andrade Moreira

Research output: Contribution to journalReview article

Abstract

Through association with cases of microcephaly in 2015, Zika virus (ZIKV) has transitioned from a relatively unknown mosquito-transmitted pathogen to a global health emergency, emphasizing the need to improve existing mosquito control programs to prevent future disease outbreaks. The response to Zika must involve a paradigm shift from traditional to novel methods of mosquito control, and according to the World Health Organization should incorporate the release of mosquitoes infected with the bacterial endosymbiont Wolbachia pipientis. In our recent paper [Dutra, HLC et al., Cell Host & Microbe 2016] we investigated the potential of Wolbachia infections in Aedes aegypti to restrict infection and transmission of Zika virus recently isolated in Brazil. Wolbachia is now well known for its ability to block or reduce infection with a variety of pathogens in different mosquito species including the dengue (DENV), yellow fever, and chikungunya viruses, and malaria-causing Plasmodium, and consequently has great potential to control mosquito-transmitted diseases across the globe. Our results demonstrated that the wMel Wolbachia strain in Brazilian Ae. aegypti is a strong inhibitor of ZIKV infection, and furthermore appears to prevent transmission of infectious viral particles in mosquito saliva, which highlights the bacterium’s suitability for more widespread use in Zika control.

Original languageEnglish (US)
Pages (from-to)293-295
Number of pages3
JournalMicrobial Cell
Volume3
Issue number7
DOIs
StatePublished - Jul 1 2016
Externally publishedYes

Fingerprint

Wolbachia
Mosquito control
Aedes
Mosquito Control
Culicidae
Viruses
Pathogens
Chikungunya virus
Yellow fever virus
Plasmodium malariae
Health
Microcephaly
Infectious Disease Transmission
Dengue
Infection
Saliva
Virion
Disease Outbreaks
Brazil
Emergencies

Keywords

  • Aedes aegypti
  • Mosquito-transmitted disease
  • Wolbachia
  • Zika virus

ASJC Scopus subject areas

  • Immunology and Microbiology (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

Inhibition of Zika virus by Wolbachia in Aedes aegypti. / Caragata, Eric; Dutra, Heverton Leandro Carneiro; Moreira, Luciano Andrade.

In: Microbial Cell, Vol. 3, No. 7, 01.07.2016, p. 293-295.

Research output: Contribution to journalReview article

Caragata, Eric ; Dutra, Heverton Leandro Carneiro ; Moreira, Luciano Andrade. / Inhibition of Zika virus by Wolbachia in Aedes aegypti. In: Microbial Cell. 2016 ; Vol. 3, No. 7. pp. 293-295.
@article{dbd68dbe7f584daba63894786d89eec8,
title = "Inhibition of Zika virus by Wolbachia in Aedes aegypti",
abstract = "Through association with cases of microcephaly in 2015, Zika virus (ZIKV) has transitioned from a relatively unknown mosquito-transmitted pathogen to a global health emergency, emphasizing the need to improve existing mosquito control programs to prevent future disease outbreaks. The response to Zika must involve a paradigm shift from traditional to novel methods of mosquito control, and according to the World Health Organization should incorporate the release of mosquitoes infected with the bacterial endosymbiont Wolbachia pipientis. In our recent paper [Dutra, HLC et al., Cell Host & Microbe 2016] we investigated the potential of Wolbachia infections in Aedes aegypti to restrict infection and transmission of Zika virus recently isolated in Brazil. Wolbachia is now well known for its ability to block or reduce infection with a variety of pathogens in different mosquito species including the dengue (DENV), yellow fever, and chikungunya viruses, and malaria-causing Plasmodium, and consequently has great potential to control mosquito-transmitted diseases across the globe. Our results demonstrated that the wMel Wolbachia strain in Brazilian Ae. aegypti is a strong inhibitor of ZIKV infection, and furthermore appears to prevent transmission of infectious viral particles in mosquito saliva, which highlights the bacterium’s suitability for more widespread use in Zika control.",
keywords = "Aedes aegypti, Mosquito-transmitted disease, Wolbachia, Zika virus",
author = "Eric Caragata and Dutra, {Heverton Leandro Carneiro} and Moreira, {Luciano Andrade}",
year = "2016",
month = "7",
day = "1",
doi = "10.15698/mic2016.07.513",
language = "English (US)",
volume = "3",
pages = "293--295",
journal = "Microbial Cell",
issn = "2311-2638",
publisher = "Shared Science Publishers OG",
number = "7",

}

TY - JOUR

T1 - Inhibition of Zika virus by Wolbachia in Aedes aegypti

AU - Caragata, Eric

AU - Dutra, Heverton Leandro Carneiro

AU - Moreira, Luciano Andrade

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Through association with cases of microcephaly in 2015, Zika virus (ZIKV) has transitioned from a relatively unknown mosquito-transmitted pathogen to a global health emergency, emphasizing the need to improve existing mosquito control programs to prevent future disease outbreaks. The response to Zika must involve a paradigm shift from traditional to novel methods of mosquito control, and according to the World Health Organization should incorporate the release of mosquitoes infected with the bacterial endosymbiont Wolbachia pipientis. In our recent paper [Dutra, HLC et al., Cell Host & Microbe 2016] we investigated the potential of Wolbachia infections in Aedes aegypti to restrict infection and transmission of Zika virus recently isolated in Brazil. Wolbachia is now well known for its ability to block or reduce infection with a variety of pathogens in different mosquito species including the dengue (DENV), yellow fever, and chikungunya viruses, and malaria-causing Plasmodium, and consequently has great potential to control mosquito-transmitted diseases across the globe. Our results demonstrated that the wMel Wolbachia strain in Brazilian Ae. aegypti is a strong inhibitor of ZIKV infection, and furthermore appears to prevent transmission of infectious viral particles in mosquito saliva, which highlights the bacterium’s suitability for more widespread use in Zika control.

AB - Through association with cases of microcephaly in 2015, Zika virus (ZIKV) has transitioned from a relatively unknown mosquito-transmitted pathogen to a global health emergency, emphasizing the need to improve existing mosquito control programs to prevent future disease outbreaks. The response to Zika must involve a paradigm shift from traditional to novel methods of mosquito control, and according to the World Health Organization should incorporate the release of mosquitoes infected with the bacterial endosymbiont Wolbachia pipientis. In our recent paper [Dutra, HLC et al., Cell Host & Microbe 2016] we investigated the potential of Wolbachia infections in Aedes aegypti to restrict infection and transmission of Zika virus recently isolated in Brazil. Wolbachia is now well known for its ability to block or reduce infection with a variety of pathogens in different mosquito species including the dengue (DENV), yellow fever, and chikungunya viruses, and malaria-causing Plasmodium, and consequently has great potential to control mosquito-transmitted diseases across the globe. Our results demonstrated that the wMel Wolbachia strain in Brazilian Ae. aegypti is a strong inhibitor of ZIKV infection, and furthermore appears to prevent transmission of infectious viral particles in mosquito saliva, which highlights the bacterium’s suitability for more widespread use in Zika control.

KW - Aedes aegypti

KW - Mosquito-transmitted disease

KW - Wolbachia

KW - Zika virus

UR - http://www.scopus.com/inward/record.url?scp=85033345749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033345749&partnerID=8YFLogxK

U2 - 10.15698/mic2016.07.513

DO - 10.15698/mic2016.07.513

M3 - Review article

AN - SCOPUS:85033345749

VL - 3

SP - 293

EP - 295

JO - Microbial Cell

JF - Microbial Cell

SN - 2311-2638

IS - 7

ER -