Abstract
To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice. Groups of 10 mice underwent a 2.5 cm dorsal skin incision with subcutaneous placement of polyvinyl alcohol sponges. Starting on the day of wounding, the following daily injections were given: (1) thymopentin (TP5), an active synthetic pentapeptide of thymopoietin, a naturally occurring thymic hormone (1 μg/day/im); (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 μg/day/im); (3) control saline solution (0.7 ml/day/im). All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured. The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice. The magnitude of the wound healing impairment induced by the two hormones was equal in the thymus-bearing and in the nude mice. The data support previous findings, which suggested that the thymus has an inhibitory effect on wound healing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 373-377 |
| Number of pages | 5 |
| Journal | Surgery |
| Volume | 106 |
| Issue number | 2 |
| State | Published - 1989 |
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- Surgery
Cite this
Inhibition of wound repair by thymic hormones. / Barbul, Adrian; Shawe, Toby; Frankel, Heidi L.; Efron, Jonathan; Wasserkrug, Hannah L.
In: Surgery, Vol. 106, No. 2, 1989, p. 373-377.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of wound repair by thymic hormones
AU - Barbul, Adrian
AU - Shawe, Toby
AU - Frankel, Heidi L.
AU - Efron, Jonathan
AU - Wasserkrug, Hannah L.
PY - 1989
Y1 - 1989
N2 - To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice. Groups of 10 mice underwent a 2.5 cm dorsal skin incision with subcutaneous placement of polyvinyl alcohol sponges. Starting on the day of wounding, the following daily injections were given: (1) thymopentin (TP5), an active synthetic pentapeptide of thymopoietin, a naturally occurring thymic hormone (1 μg/day/im); (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 μg/day/im); (3) control saline solution (0.7 ml/day/im). All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured. The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice. The magnitude of the wound healing impairment induced by the two hormones was equal in the thymus-bearing and in the nude mice. The data support previous findings, which suggested that the thymus has an inhibitory effect on wound healing.
AB - To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice. Groups of 10 mice underwent a 2.5 cm dorsal skin incision with subcutaneous placement of polyvinyl alcohol sponges. Starting on the day of wounding, the following daily injections were given: (1) thymopentin (TP5), an active synthetic pentapeptide of thymopoietin, a naturally occurring thymic hormone (1 μg/day/im); (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 μg/day/im); (3) control saline solution (0.7 ml/day/im). All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured. The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice. The magnitude of the wound healing impairment induced by the two hormones was equal in the thymus-bearing and in the nude mice. The data support previous findings, which suggested that the thymus has an inhibitory effect on wound healing.
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M3 - Article
C2 - 2763035
AN - SCOPUS:0024421119
VL - 106
SP - 373
EP - 377
JO - Surgery
JF - Surgery
SN - 0039-6060
IS - 2
ER -