Inhibition of wound repair by thymic hormones

Adrian Barbul, Toby Shawe, Heidi L. Frankel, Jonathan E. Efron, Hannah L. Wasserkrug

Research output: Contribution to journalArticlepeer-review

Abstract

To further define the role of the thymus in wound healing, we studied the effects of two thymic hormones on fibroplasia in normal euthymic and in nude athymic mice. Groups of 10 mice underwent a 2.5 cm dorsal skin incision with subcutaneous placement of polyvinyl alcohol sponges. Starting on the day of wounding, the following daily injections were given: (1) thymopentin (TP5), an active synthetic pentapeptide of thymopoietin, a naturally occurring thymic hormone (1 μg/day/im); (2) thymulin or facteur thymique serique (FTS), a naturally occurring circulating thymic hormone (0.2 μg/day/im); (3) control saline solution (0.7 ml/day/im). All mice were killed 4 weeks after wounding, and wound breaking strength and hydroxyproline content of the sponge granulomas were measured. The results show that both thymic hormones impaired wound breaking strength and reparative collagen synthesis in normal and athymic mice. The magnitude of the wound healing impairment induced by the two hormones was equal in the thymus-bearing and in the nude mice. The data support previous findings, which suggested that the thymus has an inhibitory effect on wound healing.

Original languageEnglish (US)
Pages (from-to)373-377
Number of pages5
JournalSurgery
Volume106
Issue number2
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Surgery

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