Inhibition of Urinary 17-Ketosteroid Excretion Produced by “Benemid”

Lytt I. Gardner, John F. Crigler, Claude J. Migeon

Research output: Contribution to journalArticle

Abstract

(1) The data presented demonstrate that Benemid in doses of 2 g per day per adult produced approximately 50% diminution in urinary 17-keto-steroids. This diminution was not exaggerated by increasing the dose of Benemid to 4 g per day. (2) Spectrophotometric studies showed that Benemid did not change the androsterone-dehydroisoandrosterone ratio of urinary 17-ketosteroids. (3) Urinary estrogens were diminished in one subject. In another subject this diminution was questionable. (4) Urinary 11-oxycorticosteroids (neutral reducing lipids) did not appear to be affected by Benemid.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume78
Issue number2
DOIs
StatePublished - Nov 1951

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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