Inhibition of transient outward current by intracellular ion substitution unmasks slow inward calcium current in cardiac Purkinje fibers

Eduardo Marban

Research output: Contribution to journalArticle

Abstract

The ionophore nystatin was used to replace intracellular K+ with Cs+ in calf Purkinje fibers. Such replacement inhibited the transient outward current, and unmasked a large slow inward current (Isi). These results support the involvement of K+ as a charge carrier of the transient outward current, and suggest a method for better analysis of Isi.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalPflugers Archiv European Journal of Physiology
Volume390
Issue number1
DOIs
StatePublished - Apr 1981
Externally publishedYes

Keywords

  • calcium current
  • cesium
  • nystatin
  • Purkinje fiber
  • voltage clamp

ASJC Scopus subject areas

  • Physiology

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