Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs

Bogdana Krivogorsky, Peter Grundt, Robert H Yolken, Lorraine V Brando

Research output: Contribution to journalArticle

Abstract

New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

Original languageEnglish (US)
Pages (from-to)4466-4469
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number12
DOIs
StatePublished - Dec 2008

Fingerprint

Toxoplasmosis
Toxoplasma
Isatis
Oximes
Infection
Pharmaceutical Preparations
indirubin
tryptanthrine
Therapeutics
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. / Krivogorsky, Bogdana; Grundt, Peter; Yolken, Robert H; Brando, Lorraine V.

In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 12, 12.2008, p. 4466-4469.

Research output: Contribution to journalArticle

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