TY - JOUR
T1 - Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs
AU - Krivogorsky, Bogdana
AU - Grundt, Peter
AU - Yolken, Robert
AU - Jones-Brando, Lorraine
PY - 2008/12
Y1 - 2008/12
N2 - New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
AB - New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=57049167732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57049167732&partnerID=8YFLogxK
U2 - 10.1128/AAC.00903-08
DO - 10.1128/AAC.00903-08
M3 - Article
C2 - 18824607
AN - SCOPUS:57049167732
SN - 0066-4804
VL - 52
SP - 4466
EP - 4469
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 12
ER -