Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs

Bogdana Krivogorsky, Peter Grundt, Robert Yolken, Lorraine Jones-Brando

Research output: Contribution to journalArticlepeer-review

Abstract

New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

Original languageEnglish (US)
Pages (from-to)4466-4469
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number12
DOIs
StatePublished - Dec 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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