Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs

Bogdana Krivogorsky; Peter Grundt; Robert Yolken; Lorraine Jones-Brando

doi:10.1128/AAC.00903-08

Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs

Bogdana Krivogorsky, Peter Grundt, Robert Yolken, Lorraine Jones-Brando

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

Original language	English (US)
Pages (from-to)	4466-4469
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	12
DOIs	https://doi.org/10.1128/AAC.00903-08
State	Published - Dec 2008

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs",

abstract = "New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.",

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