Abstract
New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4466-4469 |
| Number of pages | 4 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 52 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2008 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
- Infectious Diseases
Cite this
Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. / Krivogorsky, Bogdana; Grundt, Peter; Yolken, Robert H; Brando, Lorraine V.
In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 12, 12.2008, p. 4466-4469.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs
AU - Krivogorsky, Bogdana
AU - Grundt, Peter
AU - Yolken, Robert H
AU - Brando, Lorraine V
PY - 2008/12
Y1 - 2008/12
N2 - New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
AB - New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3′-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=57049167732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57049167732&partnerID=8YFLogxK
U2 - 10.1128/AAC.00903-08
DO - 10.1128/AAC.00903-08
M3 - Article
C2 - 18824607
AN - SCOPUS:57049167732
VL - 52
SP - 4466
EP - 4469
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 12
ER -