Inhibition of Tolbutamide Elimination by Cimetidine but not Ranitidine

Emily W. Cate, John F. Rogers, J. Robert Powell

Research output: Contribution to journalArticlepeer-review

Abstract

This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on tolbutamide pharmacokinetics. Twelve healthy men were given a 1‐g oral dose of tolbutamide on three occasions. Subjects were randomly assigned to three treatments in a crossover fashion: cimetidine 1,200 mg/d, ranitidine 300 mg/d, and placebo. Cimetidine significantly increased the tolbutamide area under the plasma concentration‐time curve by 20% (range, −5% to 42%), increased the elimination half‐life by 17%, and decreased the carboxytolbutamide:tolbutamide plasma ratio from 0.042 to 0.036. Ranitidine did not significantly alter tolbutamide pharmacokinetics. 1986 American College of Clinical Pharmacology

Original languageEnglish (US)
Pages (from-to)372-377
Number of pages6
JournalThe Journal of Clinical Pharmacology
Volume26
Issue number5
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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