Inhibition of the Release of Slow-Reacting Substance of Anaphylaxis in the Rat with Diethylcarbamazine

Robert P. Orange, Martin D. Valentine, K. Frank Austen

Research output: Contribution to journalArticlepeer-review

Abstract

The immunologic release of SRS-Arat with intravenously administered antigen is described. Hetrazan effectively inhibits the antigen-induced release of SRS-Arat in a dose of 20 mg/kg iv. In this concentration, it has no influence on the bioassay system and does not prevent effective antibody-antigen interaction. Hetrazan does not produce an irreversible inhibition and must be present at the time of antibody-antigen interaction to effectively prevent the formation and release of SRS-Arat. Suppression of the 4-hour PCA reaction in the rat with Hetrazan plus mepyramine maleate and methysergide suggests that SRS-Arat may be a permeability factor involved in this reaction.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume127
Issue number1
DOIs
StatePublished - Jan 1968
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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