Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

Medicine & Life Sciences

• Pancreatic Carcinoma 100%
• Phosphatidylinositol 3-Kinase 84%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 79%
• Apoptosis 50%
• Cell Line 49%
• In Vitro Techniques 36%
• Phosphorylation 34%
• MAP Kinase Kinase Kinases 22%
• Neoplasms 21%
• Wortmannin 20%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 19%
• DNA Nucleotidylexotransferase 19%
• gemcitabine 18%
• Extracellular Signal-Regulated MAP Kinases 18%
• Protein Kinase Inhibitors 17%
• Mitogens 16%
• Growth 16%
• Pancreatic Neoplasms 15%
• Staining and Labeling 10%
• Neoplasm Metastasis 10%
• Survival 9%
• Liver 8%
• Proteins 6%
• Therapeutics 2%