Inhibition of the miR-192/215-Rab11-FIP2 axis suppresses human gastric cancer progression article

Xiaojing Zhang, Yin Peng, Yong Huang, Shiqi Deng, Xianling Feng, Gangqiang Hou, Huijuan Lin, Jian Wang, Ruibin Yan, Yanqiu Zhao, Xinmin Fan, Stephen J. Meltzer, Song Li, Zhe Jin

Research output: Contribution to journalArticlepeer-review

Abstract

Less than a century ago, gastric cancer (GC) was the most common cancer throughout the world. Despite advances in surgical, chemotherapeutic, and radiotherapeutic treatment, GC remains the number 3 cancer killer worldwide. This fact highlights the need for better diagnostic biomarkers and more effective therapeutic targets. RAB11-FIP2, a member of the Rab11 family of interacting proteins, exhibits potential tumor suppressor function. However, involvement of RAB11-FIP2 in gastric carcinogenesis is yet to be elucidated. In this study, we demonstrated that RAB11-FIP2 was downregulated in GC tissues and constituted a target of the known onco-miRs, miR-192/215. We also showed that functionally, Rab11-FIP2 regulation by miR-192/215 is involved in GC-related biological activities. Finally, RAB11-FIP2 inhibition by miR-192/215 affected the establishment of cell polarity and tight junction formation in GC cells. In summary, this miR-192/215-Rab11-FIP2 axis appears to represent a new molecular mechanism underlying GC progression, while supplying a promising avenue of further research into diagnosis and therapy of GC.

Original languageEnglish (US)
Article number778
JournalCell Death and Disease
Volume9
Issue number7
DOIs
StatePublished - Jul 1 2018

ASJC Scopus subject areas

  • Immunology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'Inhibition of the miR-192/215-Rab11-FIP2 axis suppresses human gastric cancer progression article'. Together they form a unique fingerprint.

Cite this