Inhibition of the complement cascade by the major secretory protein of vaccinia virus

Girish J. Kotwal; Stuart N. Isaacs; Robin Mckenzie; Michael M. Frank; Bernard Moss

doi:10.1126/science.2237434

Inhibition of the complement cascade by the major secretory protein of vaccinia virus

Girish J. Kotwal, Stuart N. Isaacs, Robin Mckenzie, Michael M. Frank, Bernard Moss

Research output: Contribution to journal › Article › peer-review

254 Scopus citations

Abstract

The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.

Original language	English (US)
Pages (from-to)	827-830
Number of pages	4
Journal	Science
Volume	250
Issue number	4982
DOIs	https://doi.org/10.1126/science.2237434
State	Published - 1990
Externally published	Yes

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abstract = "The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.",

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AU - Kotwal, Girish J.

AU - Isaacs, Stuart N.

AU - Mckenzie, Robin

AU - Frank, Michael M.

AU - Moss, Bernard

PY - 1990

Y1 - 1990

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AB - The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.

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Inhibition of the complement cascade by the major secretory protein of vaccinia virus

Abstract

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