Inhibition of the complement cascade by the major secretory protein of vaccinia virus

Girish J. Kotwal, Stuart N. Isaacs, Robin Mckenzie, Michael M. Frank, Bernard Moss

Research output: Contribution to journalArticlepeer-review

Abstract

The complement system contributes to host defenses against invasion by infectious agents. A 35-kilodalton protein, encoded by vaccinia virus and secreted from infected cells, has sequence similarities to members of a gene family that includes complement control proteins. Biochemical and genetic studies showed that the viral protein binds to derivatives of the fourth component of complement and inhibits the classical complement cascade, suggesting that it serves as a defense molecule to help the virus evade the consequences of complement activation.

Original languageEnglish (US)
Pages (from-to)827-830
Number of pages4
JournalScience
Volume250
Issue number4982
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • General

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