Inhibition of the alloantibody response by CD95 ligand

Hiroshi Arai, Sherri Y. Chan, D. Keith Bishop, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

We investigated the effect of Fas/APO1-ligand (CD95L) gene transfer on allogenic immune responses in vivo. A colon carcinoma cell line from BALB/c mice, CT26, was stably transferred with a vector encoding mouse CD95L and was inoculated into C57BL/6 mice. CD95L expression markedly reduced allogeneic cytotoxic T lymphocyte and helper T lymphocyte activity directed toward CT26. Strikingly, expression of CD95L on these allogeneic tumors completely inhibited the generation of allonatibodies of both IgM and IgG subclasses. Thus, CD95L inhibited alloantibody production and conferred localized immune suppression through this mechanism. These results provide insight into the role of CD95L in regulating the alloantibody response and the generation of local immune responses.

Original languageEnglish (US)
Pages (from-to)843-848
Number of pages6
JournalNature Medicine
Volume3
Issue number8
DOIs
StatePublished - Aug 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Arai, H., Chan, S. Y., Bishop, D. K., & Nabel, G. J. (1997). Inhibition of the alloantibody response by CD95 ligand. Nature Medicine, 3(8), 843-848. https://doi.org/10.1038/nm0897-843