Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

Craig Montell, Eric F. Fisher, Marvin H. Caruthers, Arnold J. Berk

Research output: Contribution to journalArticlepeer-review

Abstract

A single U → G transversion in the 3′ consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3′ end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylation but is required for the cleavage step preceding polyadenylation to occur efficiently.

Original languageEnglish (US)
Pages (from-to)600-605
Number of pages6
JournalNature
Volume305
Issue number5935
DOIs
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA'. Together they form a unique fingerprint.

Cite this