Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

Abstract

A single U → G transversion in the 3′ consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3′ end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylation but is required for the cleavage step preceding polyadenylation to occur efficiently.

Original languageEnglish (US)
Pages (from-to)600-605
Number of pages6
JournalNature
Volume305
Issue number5935
DOIs
Publication statusPublished - 1983
Externally publishedYes

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ASJC Scopus subject areas

  • General

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