Inhibition of renin secretion by HCl is related to chloride in both dog and rat

T. A. Kotchen, K. E. Krzyzaniak, J. E. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

To Cl- if inhibition of renin release by HCl is related to acidosis or to C1-, the effects of peripheral venous infusions of HCl and H2SO4 on plasma renin activity (PRA) were compared in the dog and the rat. In NaCL-deprived, pentobarbital-anesthetized dogs, either 0.15M HCl (n=10) or 0.075 M H2SO4 (n=7) was infused for 60 min. In 5 of the 10 HCl-infused dogs (group A), urine Cl- excretion increased (P<0.01) during HCl infusion. In the remaining five dogs (group B), Cl- excretion did not increase. Cl- excretion also did not increase during H2SO4 infusion. Comparable acidosis was produced in all three groups. PRA decreased (P<0.01) in response to HCl in group A but did not change (P>0.8) in group B HCl-infused dogs or in H2SO4-infused dogs. In NaCl-deprived, anesthetized rats, PRA was suppressed (P<0.05) by HCl (from 40.6 ± 5.3 ng.ml-1.h-1(SE) but not H2SO4 (from 37.1 ± 4.2 to 37.0 ± 6.3 ng.ml-1.h-1), despite comparable acidosis. Cl- excretion increased on in HCl-infused rats. In conclusion, inhibition of PRA by acute infusion of HCl is specifically related to Cl-.

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume8
Issue number1
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Physiology

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